Zhang Longhui, Cao Yang, Dai Xiangpeng, Zhang Xiaoling
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China.
National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2022 Nov 1;13:1065029. doi: 10.3389/fphar.2022.1065029. eCollection 2022.
The dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome is a severe immune disorder and characterized by serum IgE levels elevation, fungal and viral infections, dermatitis and food allergies. It was well known that DOCK8 is crucial for the survival and function of multiple immune related cells. However, the critical role of DOCK8 on tumorigenesis through regulating immunity is poorly investigated. Accumulating evidences indicated that DOCK8 could affect tumorigenesis by regulating the immunity through immune cells, including NK cells, T cells, B cells and dendritic cells. Here, we summarized and discussed the critical role of DOCK8 in cytoskeleton reconstruction, CD4 T cell differentiation, immune synaptic formation, tumor immune infiltration, tumor immune surveillance and tumorigenesis. Furthermore, the potential roles of nanotechnology in improving the hematopoietic stem cell transplantation-based therapy for DOCK8 deficiency diseases are also highlighted and discussed.
胞质分裂8（DOCK8）免疫缺陷综合征是一种严重的免疫紊乱疾病，其特征为血清IgE水平升高、真菌和病毒感染、皮炎及食物过敏。众所周知，DOCK8对多种免疫相关细胞的存活和功能至关重要。然而，DOCK8通过调节免疫在肿瘤发生中的关键作用却鲜有研究。越来越多的证据表明，DOCK8可通过调节包括自然杀伤细胞、T细胞、B细胞和树突状细胞在内的免疫细胞的免疫功能来影响肿瘤发生。在此，我们总结并讨论了DOCK8在细胞骨架重建、CD4 T细胞分化、免疫突触形成、肿瘤免疫浸润、肿瘤免疫监视及肿瘤发生中的关键作用。此外，还重点介绍并讨论了纳米技术在改善基于造血干细胞移植治疗DOCK8缺陷疾病方面的潜在作用。
