Zhang Ziheng, Hu Yajun, Chen Yuefeng, Chen Zhuoneng, Zhu Yexin, Chen Mingmin, Xia Jichu, Sun Yixuan, Xu Wenfang
Medical School, Shaoxing University, Shaoxing, China.
Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China.
Front Oncol. 2022 Oct 31;12:1024789. doi: 10.3389/fonc.2022.1024789. eCollection 2022.
The tumor immune microenvironment has been a research hot spot in recent years. The cytokines and metabolites in the microenvironment can promote the occurrence and development of tumor in various ways and help tumor cells get rid of the surveillance of the immune system and complete immune escape. Many studies have shown that the existence of tumor microenvironment is an important reason for the failure of immunotherapy. The impact of the tumor microenvironment on tumor is a systematic study. The current research on this aspect may be only the tip of the iceberg, and a relative lack of integrity, may be related to the heterogeneity of tumor. This review mainly discusses the current status of glucose metabolism and lipid metabolism in the tumor microenvironment, including the phenotype of glucose metabolism and lipid metabolism in the microenvironment; the effects of these metabolic methods and their metabolites on three important immune cells Impact: regulatory T cells (Tregs), tumor-associated macrophages (TAM), natural killer cells (NK cells); and the impact of metabolism in the targeted microenvironment on immunotherapy. At the end of this article,the potential relationship between Ferroptosis and the tumor microenvironment in recent years is also briefly described.
肿瘤免疫微环境是近年来的研究热点。微环境中的细胞因子和代谢产物可通过多种方式促进肿瘤的发生发展，帮助肿瘤细胞摆脱免疫系统的监视并实现免疫逃逸。许多研究表明，肿瘤微环境的存在是免疫治疗失败的重要原因。肿瘤微环境对肿瘤的影响是一项系统性研究。目前对此方面的研究可能只是冰山一角，且相对缺乏完整性，这可能与肿瘤的异质性有关。本综述主要探讨肿瘤微环境中糖代谢和脂代谢的现状，包括微环境中糖代谢和脂代谢的表型；这些代谢方式及其代谢产物对三种重要免疫细胞的影响：调节性T细胞（Tregs）、肿瘤相关巨噬细胞（TAM）、自然杀伤细胞（NK细胞）；以及靶向微环境中的代谢对免疫治疗的影响。在本文结尾，还简要描述了近年来铁死亡与肿瘤微环境之间的潜在关系。
