Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Department of Cardiology, Xuzhou Central Hospital, Xuzhou 221009, China.
Oxid Med Cell Longev. 2022 Nov 2;2022:1723309. doi: 10.1155/2022/1723309. eCollection 2022.
The biomarkers galectin-3 (Gal-3) and endothelial cell-specific molecule 1 (ESM-1) reflect endothelial function and inflammation. As a consequence, they play an important role in both the diagnosis and characterization of ST-segment elevation myocardial infarction (STEMI). However, no prior study has explored the association between ESM-1 and Gal-3 in STEMI patients. This study is aimed at determining the ESM-1 and Gal-3 levels in the serum of STEMI patients and then exploring the correlation between the levels of these two biomarkers and their clinical significance in STEMI patients. The participants were divided into two groups: the ST group comprised 35 hospitalized STEMI patients while the control group comprised 24 people with normal coronary arteries. In all the patients, venous blood was taken from the middle of the antecubital fossa. The serum ESM-1 and Gal-3 concentrations were determined using an enzyme-linked immunosorbent assay. The results revealed that the ESM-1 and Gal-3 levels in the STEMI patients were 1.6 and 2.8 times higher, respectively, when compared with the controls ( < 0.001). Moreover, the ESM-1 and Gal-3 levels exhibited a positive linear correlation ( = 0.758, < 0.001) in the acute STEMI patients. In conclusion, the ESM-1 and Gal-3 levels were found to be significantly elevated and correlated in the STEMI patients. Thus, combining these two biomarkers of endothelial dysfunction and inflammation might be useful for the diagnosis and assessment of STEMI.
标志物半乳糖凝集素-3（Gal-3）和血管内皮细胞特异性分子 1（ESM-1）反映了内皮功能和炎症。因此，它们在 ST 段抬高型心肌梗死（STEMI）的诊断和特征描述中起着重要作用。然而，之前没有研究探讨过 ESM-1 和 Gal-3 在 STEMI 患者中的相关性。本研究旨在确定 STEMI 患者血清中的 ESM-1 和 Gal-3 水平，然后探讨这两种生物标志物水平与 STEMI 患者的临床意义之间的相关性。参与者被分为两组：ST 组包括 35 名住院 STEMI 患者，对照组包括 24 名冠状动脉正常的人。在所有患者中，从中肘窝静脉抽取静脉血。采用酶联免疫吸附试验测定血清 ESM-1 和 Gal-3 浓度。结果表明，与对照组相比，STEMI 患者的 ESM-1 和 Gal-3 水平分别升高了 1.6 倍和 2.8 倍（ < 0.001）。此外，急性 STEMI 患者的 ESM-1 和 Gal-3 水平呈正线性相关（ = 0.758， < 0.001）。总之，STEMI 患者的 ESM-1 和 Gal-3 水平显著升高且相关。因此，联合这两种内皮功能障碍和炎症的生物标志物可能有助于 STEMI 的诊断和评估。
