鸡蛋摄入量与中国成年人代谢相关因素风险的关系。

Association of egg intake with risks of cardiometabolic factors among adults in China.

机构信息

National Institute for Nutrition and Health, Chinese Center for Diseases Control and Prevention, Beijing, China.

Key Laboratory of Trace Elements and Nutrition, National Health Commission, Beijing, China.

出版信息

Front Public Health. 2022 Oct 26;10:1010539. doi: 10.3389/fpubh.2022.1010539. eCollection 2022.

DOI:10.3389/fpubh.2022.1010539

PMID:36388381

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9645429/

Abstract

OBJECTIVE

To explore the association between egg intake and cardiometabolic factors (CMFs) in Chinese adults.

METHOD

The subjects were 6,182 adults aged 18-64 who had complete survey data and had no CMFs at baseline. Egg intake was assessed with 3 days-24 h dietary recalls in all waves of the China Health and Nutrition Survey (CHNS). Multivariate Cox proportional risk regression model and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between egg intake and CMFs.

RESULTS

Of the 6,182 participants who did not have metabolic syndrome (MetS) at baseline, 1,921 developed this disease during an average follow-up of 5.71 years, with an incidence of 31.07%. Central obesity, elevated TG, decreased HDL-C, elevated blood pressure and elevated plasma glucose were 38.65, 26.74, 30.21, 40.64, and 30.64%, respectively. After adjusting for demographic characteristics, lifestyle, energy and BMI, using the lowest quintile (Q1) as a reference, the risk of central obesity, elevated TG, decreased HDL-C, and elevated plasma glucose in the highest quintile (Q5) were reduced by 15% (HR = 0.85, 95% CI = 0.73-0.98, = 0.16), 33% (HR = 0.67, 95% CI = 0.57-0.78), 25% (HR = 0.75, 95% CI = 0.63 0.90, = 0.05), and 28% (HR = 0.72, 95% CI = 0.63-0.83, < 0.05), respectively. The risk of elevated blood pressure was reduced by 26% in the fourth quintile (HR = 0.74, 95% CI = 0.64-0.85, = 0.85). RCS analysis show that the overall correlation and nonlinear relationship between egg intake and CMFs were statistically significant ( < 0.05). When the intake was lower than 20 g/days, the risk of MetS, central obesity, elevated blood pressure and elevated plasma glucose were negatively correlated with egg intake, while elevated TG was negatively correlated with eggs when the intake was lower than 60 g/days. There was no statistically significant association between egg intake and CMFs at higher egg intake.

CONCLUSION

There was a -shaped association between egg intake and CMFs in Chinese adults.

摘要

目的

探讨中国人鸡蛋摄入量与心血管代谢因素（CMFs）之间的关系。

方法

该研究纳入了 6182 名年龄在 18-64 岁之间的成年人，这些人在基线时没有 CMFs，且完成了所有轮次的中国健康与营养调查（CHNS）的 3 天-24 小时膳食回顾调查。采用多变量 Cox 比例风险回归模型和限制立方样条（RCS）模型分析鸡蛋摄入量与 CMFs 之间的关联和剂量反应关系。

结果

在 6182 名基线时没有代谢综合征（MetS）的参与者中，有 1921 人在平均 5.71 年的随访中患上了这种疾病，发病率为 31.07%。中心性肥胖、甘油三酯升高、高密度脂蛋白胆固醇降低、血压升高和血糖升高的发生率分别为 38.65%、26.74%、30.21%、40.64%和 30.64%。在调整了人口统计学特征、生活方式、能量和 BMI 后，以最低五分位（Q1）为参考，最高五分位（Q5）的中心性肥胖、甘油三酯升高、高密度脂蛋白胆固醇降低和血糖升高的风险分别降低了 15%（HR = 0.85，95%CI = 0.73-0.98， = 0.16）、33%（HR = 0.67，95%CI = 0.57-0.78， = 0.00）、25%（HR = 0.75，95%CI = 0.63-0.90， = 0.05）和 28%（HR = 0.72，95%CI = 0.63-0.83， < 0.05）。第四五分位（HR = 0.74，95%CI = 0.64-0.85， = 0.85）的血压升高风险降低了 26%。RCS 分析显示，鸡蛋摄入量与 CMFs 之间的整体相关性和非线性关系具有统计学意义（ < 0.05）。当摄入量低于 20 克/天时，鸡蛋摄入量与 MetS、中心性肥胖、血压升高和血糖升高呈负相关，而当摄入量低于 60 克/天时，鸡蛋摄入量与甘油三酯呈负相关。在更高的鸡蛋摄入量时，鸡蛋摄入量与 CMFs 之间没有统计学上的显著关联。