Yan Chengyu, Wang Lu, Ma Ning, Wan Yizhen, Zhou Lele, Zhu Xueyi, Qian Weiping
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China; OPLI (Suzhou) Biotechnology Co., Ltd, New District, Suzhou, 215163, China.
Anal Chim Acta. 2022 Dec 15;1236:340582. doi: 10.1016/j.aca.2022.340582. Epub 2022 Nov 2.
The hydrogels, because of their swelling properties in response to the environmental stimulus, are being widely considered for the design of controlled drug release systems. To meet the need for developing effective drug delivery methods, we developed special silica colloidal crystal (SCC)-embedded chitosan hydrogel films. The SCC films served as an interference substrate and drug storage layer, while the chitosan hydrogel served as a cover to regulate the drug release. The optical interferometry was performed to dynamically monitor the volume phase transition of chitosan hydrogel response to pH stimulation. Furthermore, the effects of crosslinking ratio and hydrogel thickness on the swelling properties of chitosan hydrogel were also evaluated. More importantly, the pH-responsive swelling of chitosan hydrogel was used to slowly release indomethacin. This system may provide support for drug delivery studies, therefore further expected to apply in the enhancement of the treatment efficiency of new drug therapies.
由于水凝胶在环境刺激下具有溶胀特性，因此在可控药物释放系统的设计中受到广泛关注。为满足开发有效药物递送方法的需求，我们制备了特殊的嵌入二氧化硅胶体晶体（SCC）的壳聚糖水凝胶薄膜。SCC薄膜作为干涉基底和药物储存层，而壳聚糖水凝胶作为覆盖层来调节药物释放。通过光学干涉测量法动态监测壳聚糖水凝胶对pH刺激的体积相变。此外，还评估了交联比和水凝胶厚度对壳聚糖水凝胶溶胀性能的影响。更重要的是，利用壳聚糖水凝胶的pH响应性溶胀来缓慢释放吲哚美辛。该系统可为药物递送研究提供支持，因此有望进一步应用于提高新药治疗的效率。
