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患有结核病和呼吸系统疾病的老年人群中的睡眠障碍。

Sleep disorders in elderly population suffering from TB and respiratory diseases.

作者信息

Vadakkan Devassy Thomas, Ps Nishanth, Sharma Daksh, Thomas Anjana Mary

机构信息

Department of Pulmonary Medicine, Amala Institute of Medical Sciences, India.

DM Pulmonary Medicine Resident, Department of Pulmonary Medicine, Amala Institute of Medical Sciences, India.

出版信息

Indian J Tuberc. 2022;69 Suppl 2:S272-S279. doi: 10.1016/j.ijtb.2022.10.019. Epub 2022 Oct 31.

Abstract

Sleep disorders (SD) are more frequent in the elderly population than younger counterparts. The underlying SD has a more severe impact on cardiorespiratory fitness. In elderly population with respiratory disorders, incidence and baneful influence of sleep disorders are extremely high. Insomnia in elderly is very common probably due to age related changes, underlying co morbidities and multiple medications. With aging there is decrease in duration of slow wave sleep and increase in NREM stage 1 and 2 sleep, which increases number of spontaneous arousals. Compared to younger people, elderly individuals tend to sleep earlier and wake up earlier due to changes in their normal circadian rhythm. Poor sleep quality and restless leg syndrome are higher in Tuberculosis patients. Disturbances in immune regulation due to chronic insomnia may exacerbate chronic infections like TB. Because many respiratory diseases and medications are known to cause sleep disturbances, it is important to assess treatable medical conditions and insomnia inducing medications before initiating hypnotics. Diagnosing sleep disordered breathing (SDB) in ILD patients is particularly important as nocturnal oxygen desaturation is associated with poor prognosis and could possibly be a cause of pulmonary hypertension. In patients with pulmonary hypertension (PH) and underlying obstructive sleep apnoea, CPAP therapy may help to reduce the PH. Addressing sleep disorders will be highly beneficial in elderly COPD patients with sleep disorders. This article reviews different SD, its effects and the treatment benefits in improving the quality of life and reducing the risk of progression of respiratory dysfunction in elderly population with TB and respiratory diseases.

摘要

睡眠障碍(SD)在老年人群中比在年轻人中更为常见。潜在的睡眠障碍对心肺健康有更严重的影响。在患有呼吸系统疾病的老年人群中,睡眠障碍的发生率和有害影响极高。老年人失眠非常普遍,这可能是由于与年龄相关的变化、潜在的合并症和多种药物治疗所致。随着年龄的增长,慢波睡眠的持续时间会减少,非快速眼动睡眠1期和2期会增加,这会增加自发觉醒的次数。与年轻人相比,由于正常昼夜节律的变化,老年人往往早睡早起。肺结核患者的睡眠质量差和不安腿综合征更为常见。慢性失眠导致的免疫调节紊乱可能会加重像肺结核这样的慢性感染。由于许多呼吸系统疾病和药物已知会导致睡眠障碍,在开始使用催眠药之前评估可治疗的疾病状况和导致失眠的药物非常重要。在间质性肺疾病(ILD)患者中诊断睡眠呼吸障碍(SDB)尤为重要,因为夜间氧饱和度下降与预后不良有关,并且可能是肺动脉高压的一个原因。在患有肺动脉高压(PH)和潜在阻塞性睡眠呼吸暂停的患者中,持续气道正压通气(CPAP)治疗可能有助于降低肺动脉高压。解决睡眠障碍对患有睡眠障碍的老年慢性阻塞性肺疾病(COPD)患者将非常有益。本文综述了不同的睡眠障碍、其影响以及在改善老年肺结核和呼吸系统疾病患者生活质量及降低呼吸功能障碍进展风险方面的治疗益处。

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