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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol. 1978 Sep;282:429-35. doi: 10.1113/jphysiol.1978.sp012473.

In conscious rabbits an i.v. infusion of 30 or 60 microgram E. coli pyrogen/kg body wt. decreased urine flow from control of 1.13 +/- 0.11 (S.E. of mean) ml./min to 0.43 +/- 0.09 ml./min while urine osmolality increased from 212 +/- 16 to 679 +/- 82 m-osmole/kg H2O. Clearances of exogenous creatine and p-aminohippurate did not change significantly. 2. Plasma antidiuretic activity (rat bio-assay) increased from control of 15.5 +/- 4.2 to 56.8 +/- 5.5 muu./ml. at the top of antidiuresis. 3. Comparable urine flow and osmolality changes were evoked by a pyrogen dose of only 0.2 microgram per animal injected into the lateral cerebral ventricle. 4. The results suggest that in the rabbit pyrogen stimulates ADH release by an unknown central mechanism.

在清醒的兔子中，静脉输注30或60微克/千克体重的大肠杆菌热原，使尿流量从对照值1.13±0.11（均值标准误）毫升/分钟降至0.43±0.09毫升/分钟，而尿渗透压从212±16升至679±82毫渗摩尔/千克水。外源性肌酸和对氨基马尿酸的清除率无显著变化。2. 在抗利尿作用最强时，血浆抗利尿活性（大鼠生物测定法）从对照值15.5±4.2升至56.8±5.5微单位/毫升。3. 向侧脑室注射仅0.2微克/只动物的热原剂量，可引起类似的尿流量和渗透压变化。4. 结果表明，在兔子中，热原通过一种未知的中枢机制刺激抗利尿激素释放。

J Physiol. 1978 Sep;282:429-35. doi: 10.1113/jphysiol.1978.sp012473.

In conscious rabbits an i.v. infusion of 30 or 60 microgram E. coli pyrogen/kg body wt. decreased urine flow from control of 1.13 +/- 0.11 (S.E. of mean) ml./min to 0.43 +/- 0.09 ml./min while urine osmolality increased from 212 +/- 16 to 679 +/- 82 m-osmole/kg H2O. Clearances of exogenous creatine and p-aminohippurate did not change significantly. 2. Plasma antidiuretic activity (rat bio-assay) increased from control of 15.5 +/- 4.2 to 56.8 +/- 5.5 muu./ml. at the top of antidiuresis. 3. Comparable urine flow and osmolality changes were evoked by a pyrogen dose of only 0.2 microgram per animal injected into the lateral cerebral ventricle. 4. The results suggest that in the rabbit pyrogen stimulates ADH release by an unknown central mechanism.

在清醒的兔子中，静脉输注30或60微克/千克体重的大肠杆菌热原，使尿流量从对照值1.13±0.11（均值标准误）毫升/分钟降至0.43±0.09毫升/分钟，而尿渗透压从212±16升至679±82毫渗摩尔/千克水。外源性肌酸和对氨基马尿酸的清除率无显著变化。2. 在抗利尿作用最强时，血浆抗利尿活性（大鼠生物测定法）从对照值15.5±4.2升至56.8±5.5微单位/毫升。3. 向侧脑室注射仅0.2微克/只动物的热原剂量，可引起类似的尿流量和渗透压变化。4. 结果表明，在兔子中，热原通过一种未知的中枢机制刺激抗利尿激素释放。