Independent Researcher, Abuja, Nigeria.
Rutgers School of Public Health, Piscataway, New Jersey, USA.
AIDS Res Hum Retroviruses. 2023 Feb;39(2):53-56. doi: 10.1089/AID.2022.0068. Epub 2023 Jan 10.
Improving access to grant funding is a critical aspect of strengthening research capacity outside of higher income settings, particularly in HIV/AIDS where randomized control trials (RCTs) that require substantial resources are common. In this article, we assessed recent RCTs to examine variation in how studies were funded, depending on study location and the countries where publication authors were based. We conducted a PubMed literature review to identify RCTs with HIV status or viral load endpoints published in 2019 and 2020, then analyzed cross-tabulations of funding sources by study characteristics. One hundred sixteen publications met the inclusion criteria. Research in higher income countries was most likely to be funded by biotech/pharmaceutical companies, whereas research in lower- and middle-income countries was most likely to be funded by U.S. government sources. Overall, we found the distribution of funding sources differed significantly by study and author location ( = 23, < .001). Published RCTs with HIV status or viral load endpoints are financed differently based on where studies take place and where the authors are based. As part of future research, understanding why this variation exists is critical for assessing how funding contributes to global imbalances in scientific resources.
改善获得赠款资金的机会是加强高收入环境以外的研究能力的关键方面，特别是在 HIV/AIDS 领域，因为需要大量资源的随机对照试验（RCT）很常见。在本文中，我们评估了最近的 RCT，以研究研究地点和出版物作者所在国家/地区对研究资金来源的差异。我们进行了一项 PubMed 文献综述，以确定 2019 年和 2020 年发表的 HIV 状态或病毒载量终点的 RCT，并随后分析了按研究特征划分的资金来源交叉列表。有 116 篇出版物符合纳入标准。高收入国家的研究最有可能得到生物技术/制药公司的资助，而中低收入国家的研究最有可能得到美国政府的资助。总体而言，我们发现资金来源的分布因研究和作者所在地而异（ = 23， < .001）。以 HIV 状态或病毒载量为终点的已发表 RCT 根据研究地点和作者所在地的不同，其资金来源也不同。作为未来研究的一部分，了解这种差异存在的原因对于评估资金如何导致全球科学资源不平衡至关重要。
