Terasaki Hiroto, Funatsu Ryoh, Okamura Koki, Mihara Naohisa, Shiihara Hideki, Yamashita Takehiro, Sonoda Shozo, Sakamoto Taiji
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Int J Retina Vitreous. 2025 Mar 27;11(1):37. doi: 10.1186/s40942-025-00661-w.
Effects of macular shape changes on the retina have been studied in pathologic myopia. However, whether there are individual differences in macular shape in non-pathologic myopia and the influence of macular shape on retinochoroidal disease in these eyes is not well known. A recently developed ultra-wide-field optical coherence tomography (UWF-OCT) has a wider imaging range and can be used to evaluate inferior posterior staphyloma (IPS). We aimed to investigate the effect of IPS on Haller vessel running patterns (HVRPs) in healthy eyes using UWF-OCT.
This single-center retrospective study included healthy subjects. UWF-OCT images of normal subjects were stretched vertically to enhance the macula's shape and classified into IPS (n = 16) and non-IPS (n = 113) groups with or without propensity score matching (PSM) for age, sex, and ocular axis length. The HVRPs were subjectively classified into symmetry, superior dominant, and inferior dominant. Differences in the proportions of the patterns between the two groups were compared using Fisher's exact test.
In the non-IPS group, 65 (57.5%) individuals had a symmetric pattern of Haller's vessels, 32 (28.3%) had an upper-dominant pattern, and 16 (14.1%) had a lower-dominant pattern. In the IPS group, 14 eyes (87.5%) presented an upper dominant pattern, and 2 (12.5%) presented a symmetric pattern. There was a significant difference in vascular running patterns between the two groups (P < 0.001). After the PSM, a similar trend was confirmed.
The eyes with IPS are likely to have superior dominant HVRPs compared to the non-IPS group in healthy eyes. Macular shape may play a role in HVRPs, which are involved in the pathogenesis of retinochoroidal diseases.
在病理性近视中，已对黄斑形状改变对视网膜的影响进行了研究。然而，在非病理性近视中黄斑形状是否存在个体差异以及黄斑形状对这些眼睛中视网膜脉络膜疾病的影响尚不清楚。最近开发的超广角光学相干断层扫描（UWF-OCT）具有更宽的成像范围，可用于评估后极部下方葡萄肿（IPS）。我们旨在使用UWF-OCT研究IPS对健康眼睛中哈勒血管走行模式（HVRP）的影响。
这项单中心回顾性研究纳入了健康受试者。将正常受试者的UWF-OCT图像垂直拉伸以增强黄斑形状，并根据年龄、性别和眼轴长度进行倾向评分匹配（PSM）或不进行匹配，分为IPS组（n = 16）和非IPS组（n = 113）。HVRP主观分为对称型、上方优势型和下方优势型。使用Fisher精确检验比较两组之间模式比例的差异。
在非IPS组中，65例（57.5%）个体的哈勒血管呈对称模式，32例（28.3%）呈上方优势型，16例（14.1%）呈下方优势型。在IPS组中，14只眼（87.5%）呈现上方优势型，2只眼（12.5%）呈现对称模式。两组之间的血管走行模式存在显著差异（P < 0.001）。PSM后，证实了类似的趋势。
与健康眼睛中的非IPS组相比，患有IPS的眼睛可能具有上方优势型HVRP。黄斑形状可能在HVRP中起作用，而HVRP参与视网膜脉络膜疾病的发病机制。
