Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea.
Department of Food Science & Biotechnology, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea.
J Nanobiotechnology. 2021 Jan 22;19(1):30. doi: 10.1186/s12951-021-00774-y.
The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.
Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.
In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.
基于纳米技术的产品的进步促使人们对低成本、生物相容性和易于降解的材料进行了广泛的研究。
丝胶（SER）是一种主要由甘氨酸、丝氨酸、天冬氨酸和苏氨酸氨基酸组成的蛋白质，这些氨基酸是从蚕茧（特别是家蚕和其他物种）中提取出来的。SER 是一种具有经济可行性的生物相容性材料，由于其潜在的交联反应，它可以很容易地进行功能化。此外，SER 具有内在的生物学特性，使其可以用作具有多种生物医学应用的药物制剂的成分，例如抗肿瘤、抗菌、抗氧化剂以及作为组织修复的支架，并参与转录因子调节、炎症信号分子减少、细胞凋亡刺激、间充质细胞迁移和增殖等分子机制。
在这篇综述中，讨论了基于 SER 的纳米药物（纳米粒子、胶束、薄膜、水凝胶及其混合系统）的最新创新及其在非传统治疗中的贡献，考虑了不同的分子机制来促进其治疗应用。
