Singh Priya, Singh Deepika, Sa Pratikshya, Mohapatra Priyanka, Khuntia Auromira, K Sahoo Sanjeeb
Institute of Life Sciences, Bhubaneswar, Odisha, 751023, India.
Regional Center for Biotechnology, Pali, Haryana, 121001, India.
Nanomedicine (Lond). 2021 Jun;16(14):1219-1235. doi: 10.2217/nnm-2021-0004. Epub 2021 May 17.
The outbreak of SARS-CoV-2 infection has presented the world with an urgent demand for advanced diagnostics and therapeutics to prevent, treat and control the spread of infection. Nanotechnology seems to be highly relevant in this emergency due to the unique physicochemical properties of nanomaterials which offer versatile chemical functionalization to create advanced biomedical tools. Here, nano-intervention is discussed for designing effective strategies in developing advanced personal protective equipment kits, disinfectants, rapid and cost-effective diagnostics and therapeutics against the infection. We have also highlighted the nanoparticle-based vaccination approaches and how nanoparticles can regulate the host immune system against infection. Overall, this review discusses various nanoformulations that have shown clinical relevance or can be explored in the fight against COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的爆发给全球带来了对先进诊断和治疗方法的迫切需求，以预防、治疗和控制感染的传播。由于纳米材料独特的物理化学性质，可为创造先进的生物医学工具提供多功能化学功能化，因此纳米技术在这一紧急情况中似乎具有高度相关性。在此，讨论了纳米干预措施，以设计有效的策略来开发先进的个人防护装备套件、消毒剂、针对该感染的快速且经济高效的诊断和治疗方法。我们还强调了基于纳米颗粒的疫苗接种方法，以及纳米颗粒如何调节宿主免疫系统以抵抗感染。总体而言，本综述讨论了各种已显示出临床相关性或可在抗击2019冠状病毒病中探索的纳米制剂。
