西班牙接触性皮炎登记处（REIDAC）中对异噻唑啉酮的致敏情况：2019 - 2021年的流行病学状况。
Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019-2021 epidemiological situation.
作者信息
Hernández Fernández Carlos Pelayo, Borrego Leopoldo, Mercader García Pedro, Giménez Arnau Ana María, Sánchez Pérez Javier, Silvestre Salvador Juan Francisco, González Pérez Ricardo, Sanz Sánchez Tatiana, Sánchez Gilo Araceli, Melé Ninot Gemma, Zaragoza Ninet Violeta, Miquel Miquel Francisco Javier, Carrascosa Carrillo José Manuel, Córdoba Guijarro Susana, Gatica Ortega María Elena, Ruiz González Inmaculada, Serra Baldrich Esther, Tous Romero Fátima, Rodríguez Serna Mercedes, Pastor Nieto María Antonia, Pérez Feal Patricia, Hervella Garcés Marcos, de Vega Martínez Marina, García Doval Ignacio
机构信息
Department of Dermatology, Hospital Universitario de Gran Canaria Doctor Negrín, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
出版信息
Contact Dermatitis. 2023 Mar;88(3):212-219. doi: 10.1111/cod.14251. Epub 2022 Dec 1.
BACKGROUND
Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known.
OBJECTIVES
To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones.
MATERIALS AND METHODS
We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC).
RESULTS
A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI.
CONCLUSIONS
Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon.
背景
目前西班牙对甲基异噻唑啉酮（MI）、甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）、苯并异噻唑啉酮（BIT）和辛基异噻唑啉酮（OIT）致敏的频率及危险因素尚不明确。
目的
研究四种异噻唑啉酮之间的致敏频率、危险因素及同时致敏情况。
材料与方法
我们分析了西班牙接触性皮炎登记处（REIDAC）2019年至2021年期间连续接受MI（0.2%水溶液）、MCI/MI（0.02%水溶液）、BIT（0.1%凡士林）和OIT（0.1%凡士林）斑贴试验的所有患者。
结果
共分析了2511例患者。致敏频率分别为：任何一种异噻唑啉酮15.7%、MI 6.8%、MCI/MI 4.8%、BIT 3.5%和OIT 0.5%。MI和MCI/MI致敏与职业活动、手部皮炎、洗涤剂及40岁以上年龄有关。BIT致敏与腿部皮炎及40岁以上年龄有关。约九分之一的MI阳性患者对BIT呈阳性，而五分之一的BIT阳性患者对MI呈阳性。
结论
在西班牙，对MI、MCI/MI和BIT致敏仍然很常见，而对OIT致敏则很少见。目前，对MI和MCI/MI的致敏似乎与职业有关。尽管其原因不明，但40岁以上患者对BIT的致敏更为常见。MI和BIT之间的同时致敏并不常见。
Zotero 插件