Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Neonatal Intensive Care Centre, King's College Hospital NHS Foundation Trust, London, UK.
Acta Paediatr. 2023 Feb;112(2):246-251. doi: 10.1111/apa.16598. Epub 2022 Nov 27.
To determine if the use of closed-loop automated oxygen control (CLAC) reduced the incidence and duration of hypoxemic episodes (SpO < 92%) in ventilated infants born at or above 34 weeks of gestation.
Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care (manual oxygen control) or standard care with a CLAC system (automated oxygen control) first.
Sixteen infants with a median (IQR) gestational age of 37.4 (36.6-38.8) weeks were studied at a median (IQR) postmenstrual age of 38.8 (37.4-39.8) weeks. During the automated oxygen control period, infants spent less time in hypoxemia (SpO < 92%) (p = 0.033), episodes of desaturation were shorter (p = 0.001), the time spent within target SpO range (92%-96%) was increased (p = 0.001), and the FiO delivery was lower (p = 0.018). The time spent in hyperoxemia (SpO > 96%) was reduced during automated oxygen control (p = 0.011), the episodes of hyperoxemia were of shorter duration (p = 0.008) and fewer manual adjustments were made to the FiO (p = 0.005).
Closed-loop automated oxygen control in ventilated infants born at or near term was associated with a reduction in the incidence and duration of hypoxemic episodes with more time spent in the target oxygen range.
确定闭环自动氧控（CLAC）是否降低了胎龄在 34 周或以上的通气婴儿低氧血症发作（SpO₂<92%）的发生率和持续时间。
连续两天对婴儿进行 6 小时的研究，每天随机接受标准护理（手动氧控）或标准护理加 CLAC 系统（自动氧控）。
16 名婴儿的中位（IQR）胎龄为 37.4（36.6-38.8）周，中位（IQR）校正后年龄为 38.8（37.4-39.8）周。在自动氧控期间，婴儿处于低氧血症（SpO₂<92%）的时间减少（p=0.033），饱和度下降的时间缩短（p=0.001），处于目标 SpO₂范围（92%-96%）的时间增加（p=0.001），FiO₂的输送减少（p=0.018）。在自动氧控时，处于高氧血症（SpO₂>96%）的时间减少（p=0.011），高氧血症发作的持续时间更短（p=0.008），FiO₂的手动调整次数减少（p=0.005）。
在接近足月出生的通气婴儿中使用闭环自动氧控与低氧血症发作的发生率和持续时间减少相关，更多时间处于目标氧范围。
