协调民族地域多样化的数据集，推进全球痴呆症流行病学研究。
Harmonizing Ethno-Regionally Diverse Datasets to Advance the Global Epidemiology of Dementia.
机构信息
Centre for Healthy Brain Ageing, University of New South Wales, Level 1, AGSM (G27), Gate 11, Botany Street, Sydney, New South Wales 2052, Australia.
Centre for Healthy Brain Ageing, University of New South Wales, Level 1, AGSM (G27), Gate 11, Botany Street, Sydney, New South Wales 2052, Australia.
出版信息
Clin Geriatr Med. 2023 Feb;39(1):177-190. doi: 10.1016/j.cger.2022.07.009. Epub 2022 Oct 18.
Understanding dementia and cognitive impairment is a global effort needing data from multiple sources across diverse ethno-regional groups. Methodological heterogeneity means that these data often require harmonization to make them comparable before analysis. We discuss the benefits and challenges of harmonization, both retrospective and prospective, broadly and with a focus on data types that require particular sorts of approaches, including neuropsychological test scores and neuroimaging data. Throughout our discussion, we illustrate general principles and give examples of specific approaches in the context of contemporary research in dementia and cognitive impairment from around the world.
了解痴呆症和认知障碍是一项全球性的努力，需要来自不同种族和地区群体的多种来源的数据。方法学的异质性意味着这些数据通常需要在分析之前进行协调，以使其具有可比性。我们广泛讨论了回顾性和前瞻性协调的好处和挑战，并特别关注需要特定方法的数据集，包括神经心理学测试分数和神经影像学数据。在整个讨论过程中，我们举例说明了一般性原则，并在世界各地关于痴呆症和认知障碍的当代研究背景下介绍了具体方法的实例。
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