Daneji Sulaiman Muhammad, Aminu Aliyu, Borodo Awwal Musa, Dayyab Farouq Muhammad
Department of Obstetrics and Gynaecology, College of Health Sciences, Bayero University, Kano, Nigeria (Dr Daneji).
Department of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University, Kano, Nigeria (Dr Aminu).
AJOG Glob Rep. 2022 Nov;2(4):100130. doi: 10.1016/j.xagr.2022.100130. Epub 2022 Nov 5.
Monkeypox is a viral zoonosis caused by the monkeypox virus, an enveloped, double-stranded DNA virus belonging to the Orthopoxvirus genus in the Poxviridae family. Monkeypox has become a disease of global public health significance. Pregnant women are unfortunately among the those at an increased risk for exposure to monkeypox because their immune system is altered during pregnancy. They may also be at risk for more severe disease or a worse outcome than others. During pregnancy or while breastfeeding when consideration is given for pre-exposure or postexposure vaccination, nonreplicating (Modivied Vaccinia Ankara - Bavarian Nordic) or minimally replicating (LC16, KM Biologics) vaccines are preferred. The ACAM2000 vaccine is contraindicated in pregnancy because it contains live virus particles that can cause fetal vaccinia and fetal death. There are no data to support the use of tecovirimat in pregnant women. However, no fetal adverse effects were noticed when tecovirimat was used in animal studies.
猴痘是一种由猴痘病毒引起的病毒性人畜共患病，猴痘病毒是一种包膜双链DNA病毒，属于痘病毒科正痘病毒属。猴痘已成为具有全球公共卫生意义的疾病。不幸的是，孕妇是接触猴痘风险增加的人群之一，因为她们在孕期免疫系统会发生改变。她们患更严重疾病或出现比其他人更差结局的风险也可能更高。在孕期或哺乳期考虑进行暴露前或暴露后接种疫苗时，首选非复制型（安卡拉痘苗病毒-巴伐利亚北欧公司）或最低限度复制型（LC16，KM生物制品公司）疫苗。ACAM2000疫苗在孕期禁忌使用，因为它含有可导致胎儿痘苗和胎儿死亡的活病毒颗粒。没有数据支持在孕妇中使用特考韦瑞。然而，在动物研究中使用特考韦瑞时未发现胎儿有不良反应。
