Department of Biological Sciences, College of Environment and Life Sciences, University of Rhode Island, Kingston, RI, United States.
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
Front Cell Infect Microbiol. 2022 Nov 2;12:1049646. doi: 10.3389/fcimb.2022.1049646. eCollection 2022.
is one of the predominant vectors of , the agent of Lyme disease in the USA. The geographic distribution of , endemic to the northeastern and northcentral USA, is expanding as far south as Georgia and Texas, and northwards into Canada and poses an impending public health problem. The prevalence and spread of tick-borne diseases are influenced by the interplay of multiple factors including microbiological, ecological, and environmental. Molecular studies have focused on interactions between the tick-host and pathogen/s that determine the success of pathogen acquisition by the tick and transmission to the mammalian host. In this review we draw attention to additional critical environmental factors that impact tick biology and tick-pathogen interactions. With a focus on we highlight the interplay of abiotic factors such as temperature and humidity as well as biotic factors such as environmental microbiota that ticks are exposed to during their on- and off-host phases on tick, and infection prevalence. A molecular understanding of this ensemble of interactions will be essential to gain new insights into the biology of tick-pathogen interactions and to develop new approaches to control ticks and tick transmission of , the agent of Lyme disease.
是导致莱姆病的病原体在美国的主要传播媒介之一。分布于美国东北部和中北部的，其地理分布范围正在向南扩展到佐治亚州和德克萨斯州，向北扩展到加拿大，并构成了即将出现的公共卫生问题。蜱传疾病的流行和传播受到多种因素的相互作用的影响，包括微生物学、生态学和环境因素。分子研究主要集中在蜱-宿主和病原体/寄生虫之间的相互作用上，这些相互作用决定了病原体被蜱获取并传播给哺乳动物宿主的成功率。在这篇综述中，我们提请注意其他影响蜱生物学和蜱-病原体相互作用的关键环境因素。我们重点关注非生物因素，如温度和湿度，以及生物因素，如蜱在其宿主和非宿主阶段接触到的环境微生物群，这些因素会影响蜱的感染率。对这种相互作用的整体的分子理解对于深入了解蜱-病原体相互作用的生物学以及开发控制蜱和莱姆病病原体传播的新方法至关重要。
