Syed Ameena, Vanka Sai Aishwarya, Escudero Ivan, Ismail Rana, Krayem Hicham
Department of Internal Medicine, Detroit Medical Center-DMC/Wayne State University/Sinai Grace Hospital, Detroit, USA.
Department of Internal Medicine, Albert Einstein College of Medicine-Montefiore Medical Center, Wakefield Campus, New York, USA.
Cureus. 2022 Oct 14;14(10):e30298. doi: 10.7759/cureus.30298. eCollection 2022 Oct.
Cancers of the thyroid gland are uncommon, accounting for 1% of malignant tumors. Oncocytic carcinoma of the thyroid (OCA), previously known as "Hürthle cell" carcinomas, make up 3% to 5% of all thyroid cancers and are extremely rare. In the United States, the incidence of thyroid cancer is approximately 12 per 100,000 per year and increases with age. The prevalence of thyroid cancers in women is estimated to be twice that in men, with the male gender correlating with a worse prognosis. A definitive diagnosis of OCA is confirmed after complete excision and histopathological examination. OCA is an aggressive tumor with an exceedingly low incidence, a high risk of metastasis, and a poor prognosis. The mainstay of therapy for OCA is surgery. In order to recognize and treat the disease as early as possible, healthcare providers must consider the probability of OCA in patients presenting with a thyroid mass. We hereby present a case of OCA identified incidentally status post tracheostomy and subsequent biopsy. We have an opportunity to review this disease with the hope of improving outcomes by raising awareness and with early recognition.
甲状腺癌并不常见,占恶性肿瘤的1%。甲状腺嗜酸细胞癌(OCA),以前称为“许特耳细胞”癌,占所有甲状腺癌的3%至5%,极为罕见。在美国,甲状腺癌的发病率约为每年每10万人中有12例,且随年龄增长而增加。据估计,女性甲状腺癌的患病率是男性的两倍,男性患者的预后较差。OCA的确诊需在完整切除并进行组织病理学检查之后。OCA是一种侵袭性肿瘤,发病率极低,转移风险高,预后不良。OCA的主要治疗方法是手术。为了尽早识别和治疗该病,医疗服务提供者必须考虑甲状腺肿物患者患OCA的可能性。我们在此报告一例气管切开术后偶然发现并经后续活检确诊的OCA病例。我们有机会回顾这种疾病,希望通过提高认识和早期识别来改善治疗效果。