Greenspan Neil S, Pereda Guillermo A
Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
Pathog Immun. 2022 Nov 10;7(2):78-92. doi: 10.20411/pai.v7i2.542. eCollection 2022.
We consider the multiple senses of several key terms that are used to discuss the ongoing COVID-19 pandemic and clarify meanings of the corresponding concepts. Topics addressed include: 1) the meaning of immunity to an infectious agent in varying medical and scientific contexts, 2) the scientific factors that influenced the rapid generation and clinical implementation of safe and effective vaccines for COVID-19, 3) the difference between mutational abrogation of reactivity with B- or T-cell antigen receptors (immune escape) versus active interference with host immune mechanisms mediated by gene products encoded within the genome of the infectious agent (immune evasion), 4) the different ways by which the COVID-19 pandemic has "caused" deaths, and 5) briefly, the challenge of precisely defining the term .
我们考虑了用于讨论当前新冠疫情的几个关键术语的多种含义，并阐明了相应概念的意义。涉及的主题包括：1）在不同医学和科学背景下对感染因子免疫的含义；2）影响新冠病毒安全有效疫苗快速研发和临床应用的科学因素；3）与B细胞或T细胞抗原受体反应性的突变消除（免疫逃逸）与由感染因子基因组中编码的基因产物介导的对宿主免疫机制的主动干扰（免疫逃避）之间的区别；4）新冠疫情“导致”死亡的不同方式；5）简要介绍了精确定义该术语的挑战。
