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High prevalence of persistent smell loss and qualitative smell dysfunction during the coronavirus disease 2019 (COVID-19) pandemic in the United States: Urgent need for clinical trials.美国2019冠状病毒病（COVID-19）大流行期间持续性嗅觉丧失和嗅觉质量功能障碍的高患病率：迫切需要进行临床试验。
Int Forum Allergy Rhinol. 2023 Aug;13(8):1558-1560. doi: 10.1002/alr.23100. Epub 2022 Nov 29.
2
Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis.目的：与主观方法相比，客观感觉测试方法显示 COVID-19 阳性患者的嗅觉丧失发生率更高：系统评价和荟萃分析。
Chem Senses. 2020 Dec 5;45(9):865-874. doi: 10.1093/chemse/bjaa064.
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Olfactory-related Quality of Life Adjustments in Smell Loss during the Coronavirus-19 Pandemic.新冠疫情期间嗅觉丧失相关的生活质量调整。
Am J Rhinol Allergy. 2022 Mar;36(2):253-260. doi: 10.1177/19458924211053118. Epub 2021 Oct 27.
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Prevalence and Prognostic Factors Associated with Early Recovery of Olfactory Dysfunction in COVID-19 Patients.新冠病毒感染患者嗅觉功能障碍早期恢复的患病率及相关预后因素
Ear Nose Throat J. 2024 Jun;103(1_suppl):68S-75S. doi: 10.1177/01455613231202207. Epub 2023 Sep 25.
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The Importance of Considering Olfactory Dysfunction During the COVID-19 Pandemic and in Clinical Practice.重视 COVID-19 大流行期间及临床实践中的嗅觉功能障碍
J Allergy Clin Immunol Pract. 2021 Jan;9(1):7-12. doi: 10.1016/j.jaip.2020.10.036. Epub 2020 Oct 28.
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[Loss of smell, a preliminary indicator of COVID-19].[嗅觉丧失，新冠病毒病的一个初步指标]
Rev Med Inst Mex Seguro Soc. 2021 Feb 2;59(1):4-6. doi: 10.24875/RMIMSS.M21000046.
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Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.嗅觉和味觉障碍作为冠状病毒病（COVID-19）轻至中度形式的临床特征：一项多中心欧洲研究。
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. doi: 10.1007/s00405-020-05965-1. Epub 2020 Apr 6.
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Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell.新型冠状病毒肺炎患者嗅觉障碍：嗅觉恢复的患病率和预后。
Otolaryngol Head Neck Surg. 2021 Jan;164(1):82-86. doi: 10.1177/0194599820943530. Epub 2020 Jul 14.
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Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study.COVID-19 大流行期间新发嗅觉丧失后的早期康复 - 一项观察性队列研究。
J Otolaryngol Head Neck Surg. 2020 May 4;49(1):26. doi: 10.1186/s40463-020-00423-8.
10
Persistent Smell Loss Following Undetectable SARS-CoV-2.持续嗅觉丧失后 SARS-CoV-2 检测呈阴性。
Otolaryngol Head Neck Surg. 2020 Nov;163(5):923-925. doi: 10.1177/0194599820934769. Epub 2020 Jun 9.

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1
The Development and Validation of the Smell-Qx Questionnaire, Based on a Systematic Review of the Literature and the COMET Initiative on the Development of Core Outcome Sets for Clinical Trials in Olfactory Disorders.基于对嗅觉障碍临床试验核心结局集文献的系统综述及COMET计划，开发并验证嗅觉问卷Smell-Qx
Int Forum Allergy Rhinol. 2025 Sep;15(9):974-984. doi: 10.1002/alr.23604. Epub 2025 May 9.
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Self-supervised learning for classifying paranasal anomalies in the maxillary sinus.基于自监督学习的上颌窦内鼻窦异常分类
Int J Comput Assist Radiol Surg. 2024 Sep;19(9):1713-1721. doi: 10.1007/s11548-024-03172-5. Epub 2024 Jun 8.
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Olfactory immune response to SARS-CoV-2.对 SARS-CoV-2 的嗅觉免疫反应。
Cell Mol Immunol. 2024 Feb;21(2):134-143. doi: 10.1038/s41423-023-01119-5. Epub 2023 Dec 25.
4
Assessment of anosmia/hyposmia in post-COVID-19 patients: a cross-sectional study in an eastern province of Saudi Arabia.评估 COVID-19 后患者的嗅觉丧失/嗅觉减退：沙特阿拉伯东部省份的一项横断面研究。
Acta Biomed. 2023 Dec 5;94(6):e2023259. doi: 10.23750/abm.v94i6.15130.

本文引用的文献

1
The burden of olfactory dysfunction during the COVID-19 pandemic in the United Kingdom.
Rhinology. 2023 Feb 1;61(1):93-96. doi: 10.4193/Rhin22.232.
2
The COVANOS trial - insight into post-COVID olfactory dysfunction and the role of smell training.COVANOS试验——对新冠后嗅觉功能障碍及嗅觉训练作用的洞察
Rhinology. 2022 Jun 1;60(3):188-199. doi: 10.4193/Rhin21.470.
3
Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves.新冠病毒感染者嗅觉和味觉功能障碍的预后和持续性：使用参数治愈模型对恢复曲线进行荟萃分析。
BMJ. 2022 Jul 27;378:e069503. doi: 10.1136/bmj-2021-069503.
4
Qualitative Olfactory Disorders: Patient Experiences and Self-Management.定性嗅觉障碍：患者体验与自我管理
Allergy Rhinol (Providence). 2021 Sep 22;12:21526567211004251. doi: 10.1177/21526567211004251. eCollection 2021 Jan-Dec.
5
Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19.嗅觉和味觉改变：嗅觉障碍、幻嗅及长新冠的影响。
PLoS One. 2021 Sep 24;16(9):e0256998. doi: 10.1371/journal.pone.0256998. eCollection 2021.
6
Confronting Our Next National Health Disaster - Long-Haul Covid.直面我们的下一场全国性健康灾难——长期新冠。
N Engl J Med. 2021 Aug 12;385(7):577-579. doi: 10.1056/NEJMp2109285. Epub 2021 Jun 30.
7
Clinical Outcomes for Patients With Anosmia 1 Year After COVID-19 Diagnosis.新冠病毒病确诊1年后嗅觉丧失患者的临床结局
JAMA Netw Open. 2021 Jun 1;4(6):e2115352. doi: 10.1001/jamanetworkopen.2021.15352.
8
Anosmia and hyposmia in health-care workers with undiagnosed SARS-CoV-2 infection.未确诊的新型冠状病毒2型感染医护人员的嗅觉丧失和嗅觉减退
Lancet Microbe. 2020 Aug;1(4):e150. doi: 10.1016/S2666-5247(20)30096-3. Epub 2020 Aug 6.
9
Psychophysical Olfactory Tests and Detection of COVID-19 in Patients With Sudden Onset Olfactory Dysfunction: A Prospective Study.突发嗅觉功能障碍患者的心理物理学嗅觉测试与新型冠状病毒肺炎检测：一项前瞻性研究
Ear Nose Throat J. 2020 Nov;99(9):579-583. doi: 10.1177/0145561320929169. Epub 2020 May 29.

High prevalence of persistent smell loss and qualitative smell dysfunction during the coronavirus disease 2019 (COVID-19) pandemic in the United States: Urgent need for clinical trials.

作者信息

Lechner Matt, Liu Jacklyn, Counsell Nicholas, Yan Carol H, Paun Santdeep, Eynon-Lewis Nicholas, Sutton Liam, Jayaraj Samuel, Batterham Rachel L, Hopkins Claire, Philpott Carl, Lund Valerie J, Hatter Matthew, Abdelwahab Mohamed, Holsinger F Christopher, Capasso Robson, Nayak Jayakar V, Hwang Peter H, Patel Zara M

机构信息

ENT Department, Barts Health NHS Trust, London, UK.

UCL Cancer Institute, University College London, London, UK.

出版信息

Int Forum Allergy Rhinol. 2023 Aug;13(8):1558-1560. doi: 10.1002/alr.23100. Epub 2022 Nov 29.

DOI:10.1002/alr.23100
PMID:36409559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10199954/
Abstract
摘要