Schelling F
Med Hypotheses. 1986 Oct;21(2):141-8. doi: 10.1016/0306-9877(86)90003-4.
Unequal propagation of central venous excess pressure into the different cerebral and spinal venous drainage systems is the rule rather than the exception. The intensity of the forces thus to be exerted on vulnerable cerebrospinal structures by the resulting pressure-gradients in the craniovertebral space is unknown. There is a need to consider the various conditions which may cause individual proneness to heavier reflux into particular cerebral as well as epi- and subdural spinal venous compartments. An attempt is made to indicate eventual consequences of excessive retrograde dilatation especially of internal cerebral veins. The importance of elucidating the neuropathological and clinical implications of undue reflux into the skull or spine is deduced from the probability of relations between localized backflow into the craniovertebral space and unexplicated cerebrospinal diseases. In this regard the features of multiple sclerosis are discussed.
中心静脉压过高在不同的脑和脊髓静脉引流系统中不均衡传播是普遍现象而非个别情况。由此在颅椎间隙产生的压力梯度作用于脆弱的脑脊液结构上的力的强度尚不清楚。有必要考虑各种可能导致个体更容易向特定脑区以及硬脊膜外和硬脊膜下脊髓静脉腔出现较重反流的情况。本文试图指出过度逆行扩张尤其是大脑内静脉过度逆行扩张的最终后果。鉴于颅椎间隙局部逆流与不明原因的脑脊液疾病之间可能存在关联，推断出阐明颅骨或脊柱过度逆流的神经病理学和临床意义的重要性。在这方面，还讨论了多发性硬化的特征。
