phylogenetic analysis of wesselsbron virus isolated from field-captured mosquitoes during a rift valley fever outbreak in kabale district, uganda-2016.
Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda-2016.
机构信息
Department of Arbovirology, Emerging, and Re-emerging Diseases, Uganda Virus Research Institute, Entebbe, Uganda.
U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
出版信息
Am J Trop Med Hyg. 2022 Nov 21;108(1):161-164. doi: 10.4269/ajtmh.22-0481. Print 2023 Jan 11.
After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify species most likely involved in Rift Valley fever virus transmission. This information could be used to forecast risk and facilitate improvement of prevention and response tools for use in preventing or controlling future outbreaks. From these collections, two virus isolates were obtained, one each from a pool of Aedes tricholabis and Ae. gibbinsi. Next-generation sequencing identified both isolates as Wesselsbron virus, family Flaviviridae, a neglected arbovirus of economic importance. These are the first reported Wesselsbron virus isolates from Uganda since 1966.
在 2016 年 3 月乌干达卡巴莱地区确认两例裂谷热（RVF）人类病例后，进行了一项昆虫学调查，重点关注蚊子物种组成和已知及潜在的蚊子媒介物种的丰度，以及病毒检测，以确定最有可能参与裂谷热病毒传播的物种。这些信息可用于预测风险，并有助于改进预防和应对工具，以防止或控制未来的疫情爆发。从这些采集物中，获得了两个病毒分离株，分别来自伊蚊属三斑库蚊和致倦库蚊的蚊群。下一代测序确定这两个分离株均为韦塞尔布隆病毒，黄病毒科，一种被忽视的具有经济重要性的虫媒病毒。这是自 1966 年以来首次报告从乌干达分离出的韦塞尔布隆病毒。
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