Raman Shreya R, Liu Christopher, Herremans Kelly M, Riner Andrea N, Vudatha Vignesh, Freudenberger Devon C, McKinley Kelley L, Triplett Eric W, Trevino Jose G
Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, Canada.
Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Microorganisms. 2022 Nov 18;10(11):2291. doi: 10.3390/microorganisms10112291.
Cancer cachexia is a multifactorial wasting syndrome associated with skeletal muscle and adipose tissue loss, as well as decreased appetite. It affects approximately half of all cancer patients and leads to a decrease in treatment efficacy, quality of life, and survival. The human microbiota has been implicated in the onset and propagation of cancer cachexia. Dysbiosis, or the imbalance of the microbial communities, may lead to chronic systemic inflammation and contribute to the clinical phenotype of cachexia. Though the relationship between the gut microbiome, inflammation, and cachexia has been previously studied, the oral microbiome remains largely unexplored. As the initial point of digestion, the oral microbiome plays an important role in regulating systemic health. Oral dysbiosis leads to the upregulation of pro-inflammatory cytokines and an imbalance in natural flora, which in turn may contribute to muscle wasting associated with cachexia. Reinstating this equilibrium with the use of prebiotics and probiotics has the potential to improve the quality of life for patients suffering from cancer-related cachexia.
癌症恶病质是一种多因素导致的消耗综合征，与骨骼肌和脂肪组织流失以及食欲下降有关。它影响着约一半的癌症患者，并导致治疗效果、生活质量和生存率下降。人体微生物群已被认为与癌症恶病质的发生和发展有关。生态失调，即微生物群落的失衡，可能导致慢性全身炎症，并促成恶病质的临床表型。尽管肠道微生物群、炎症和恶病质之间的关系此前已被研究，但口腔微生物群在很大程度上仍未被探索。作为消化的起点，口腔微生物群在调节全身健康方面发挥着重要作用。口腔生态失调会导致促炎细胞因子上调和自然菌群失衡，进而可能导致与恶病质相关的肌肉消耗。使用益生元和益生菌恢复这种平衡有可能改善患有癌症相关恶病质患者的生活质量。
