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用于前列腺癌临床诊断与治疗的人工智能

Artificial Intelligence for Clinical Diagnosis and Treatment of Prostate Cancer.

作者信息

Rabaan Ali A, Bakhrebah Muhammed A, AlSaihati Hajir, Alhumaid Saad, Alsubki Roua A, Turkistani Safaa A, Al-Abdulhadi Saleh, Aldawood Yahya, Alsaleh Abdulmonem A, Alhashem Yousef N, Almatouq Jenan A, Alqatari Ahlam A, Alahmed Hejji E, Sharbini Dalal A, Alahmadi Arwa F, Alsalman Fatimah, Alsayyah Ahmed, Mutair Abbas Al

机构信息

Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.

College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.

出版信息

Cancers (Basel). 2022 Nov 14;14(22):5595. doi: 10.3390/cancers14225595.

Abstract

As medical science and technology progress towards the era of "big data", a multi-dimensional dataset pertaining to medical diagnosis and treatment is becoming accessible for mathematical modelling. However, these datasets are frequently inconsistent, noisy, and often characterized by a significant degree of redundancy. Thus, extensive data processing is widely advised to clean the dataset before feeding it into the mathematical model. In this context, Artificial intelligence (AI) techniques, including machine learning (ML) and deep learning (DL) algorithms based on artificial neural networks (ANNs) and their types, are being used to produce a precise and cross-sectional illustration of clinical data. For prostate cancer patients, datasets derived from the prostate-specific antigen (PSA), MRI-guided biopsies, genetic biomarkers, and the Gleason grading are primarily used for diagnosis, risk stratification, and patient monitoring. However, recording diagnoses and further stratifying risks based on such diagnostic data frequently involves much subjectivity. Thus, implementing an AI algorithm on a PC's diagnostic data can reduce the subjectivity of the process and assist in decision making. In addition, AI is used to cut down the processing time and help with early detection, which provides a superior outcome in critical cases of prostate cancer. Furthermore, this also facilitates offering the service at a lower cost by reducing the amount of human labor. Herein, the prime objective of this review is to provide a deep analysis encompassing the existing AI algorithms that are being deployed in the field of prostate cancer (PC) for diagnosis and treatment. Based on the available literature, AI-powered technology has the potential for extensive growth and penetration in PC diagnosis and treatment to ease and expedite the existing medical process.

摘要

随着医学科学技术迈向“大数据”时代,与医学诊断和治疗相关的多维数据集正变得可用于数学建模。然而,这些数据集常常不一致、有噪声,且通常具有高度冗余的特征。因此,广泛建议在将数据集输入数学模型之前进行大量数据处理以清理数据集。在这种背景下,人工智能(AI)技术,包括基于人工神经网络(ANNs)及其类型的机器学习(ML)和深度学习(DL)算法,正被用于生成临床数据的精确横截面图示。对于前列腺癌患者,源自前列腺特异性抗原(PSA)、MRI引导活检、基因生物标志物和 Gleason分级的数据集主要用于诊断、风险分层和患者监测。然而,基于此类诊断数据记录诊断结果并进一步对风险进行分层常常涉及很多主观性。因此,在个人电脑的诊断数据上实施AI算法可以减少该过程的主观性并协助决策。此外,AI用于减少处理时间并有助于早期检测,这在前列腺癌的危急病例中能带来更好的结果。此外,这还通过减少人力数量有助于以更低成本提供服务。在此,本综述的主要目的是对目前在前列腺癌(PC)诊断和治疗领域中部署的现有AI算法进行深入分析。基于现有文献,人工智能驱动的技术在前列腺癌诊断和治疗中具有广泛增长和渗透的潜力,以简化和加速现有的医疗流程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5227/9688370/6fddaa97b3bb/cancers-14-05595-g001.jpg

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