Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.
Cells. 2022 Nov 11;11(22):3575. doi: 10.3390/cells11223575.
Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR-126-5p, miR-149-3p, miR-379-5p, miR-665, miR-34a-5p, miR-186-5p, miR-138-5p, miR-181c-5p, miR-98, miR-195-5p, miR-224-5p, miR-3619, miR-708, miR-101, miR-1224-5p, miR-34a-5p, and miR-142-5p. Via influencing expression of these miRNAs, it can enhance expression of a number of oncogenes. Moreover, LINC00665 can influence activity of Wnt/β-Catenin, TGF-β, MAPK1, NF-κB, ERK, and PI3K/AKT signaling. Function of this lncRNA has been assessed through gain-of-function tests and/or loss-of-function studies. Furthermore, diverse research groups have evaluated its expression levels in tissue samples using microarray and RT-qPCR techniques. In this manuscript, we have summarized the results of these studies and categorized them in three sections, i.e., cell line studies, animal studies, and investigations in clinical samples.
长链非编码 RNA 665（LINC00665）是位于 19 号染色体负链上的 RNA 基因。该 lncRNA 作为 miR-4458、miR-379-5p、miR-551b-5p、miR-3619-5p、miR-424-5p、miR-9-5p、miR-214-3p、miR-126-5p、miR-149-3p、miR-379-5p、miR-665、miR-34a-5p、miR-186-5p、miR-138-5p、miR-181c-5p、miR-98、miR-195-5p、miR-224-5p、miR-3619、miR-708、miR-101、miR-1224-5p、miR-34a-5p 和 miR-142-5p 的竞争性内源 RNA。通过影响这些 miRNA 的表达，它可以增强许多癌基因的表达。此外，LINC00665 可以影响 Wnt/β-Catenin、TGF-β、MAPK1、NF-κB、ERK 和 PI3K/AKT 信号通路的活性。通过功能获得试验和/或功能丧失研究评估了该 lncRNA 的功能。此外，不同的研究小组使用微阵列和 RT-qPCR 技术评估了其在组织样本中的表达水平。在本手稿中，我们总结了这些研究的结果，并将其分为三个部分，即细胞系研究、动物研究和临床样本研究。
