The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei, China.
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Selenium and Human Health Institute, Enshi, Hubei, China.
J Nutr Biochem. 2023 Mar;113:109230. doi: 10.1016/j.jnutbio.2022.109230. Epub 2022 Nov 23.
Imbalanced nutrient intake causes abnormal energy metabolism, which results in obesity. There is feasible evidence that selenium-rich (Se-rich) foods may alleviate obesity and enhance general public health, but the underlying mechanisms remain elusive. Herein we examined the effect of Se supplementation on white adipose tissue beiging process. The mice were fed with a normal diet or a Se-deficient high-fat diet (DHFD) until significant differences in terms of body weight, glucose tolerance and insulin sensitivity. Next, mice in the DHFD group were changed to a high-fat diet (HFD) containing specified amounts of selenomethionine (SeMet) (0, 150, 300, and 600 μg/kg) and continued to feed for 14 weeks. Notably, 150 μg/kg SeMet supplement highly protected mice from DHFD-induced obesity, insulin resistance, and lipid deposits in the liver and kidney, and featured by the enhanced beiging process in white adipose tissue and increased energy expenditure. Moreover, upon cold challenge, 150 μg/kg SeMet supplement enhanced cold tolerance in mice by inducing adipose beiging to promote energy expenditure, as evidenced by the increased expression of uncoupling protein-1 (UCP1) in adipocytes. Similarly, SeMet (10 μM) promoted the differentiation of beige adipocytes from the stromal vascular fraction. Collectively, our data support that optimal supplementation of SeMet could enhance the beiging process to attenuate HFD-induced obesity, which provides new insights into the relationship between dietary SeMet and type 2 diabetes.
营养摄入不平衡会导致能量代谢异常，从而导致肥胖。有可靠证据表明，富硒（Se-rich）食物可能减轻肥胖并增强公众健康，但潜在机制仍不清楚。在此，我们研究了硒补充对白色脂肪组织米色化过程的影响。将小鼠喂食正常饮食或硒缺乏高脂肪饮食（DHFD），直到体重、葡萄糖耐量和胰岛素敏感性出现明显差异。然后，将 DHFD 组的小鼠改为含有特定量硒蛋氨酸（SeMet）的高脂肪饮食（HFD）（0、150、300 和 600μg/kg），并继续喂养 14 周。值得注意的是，150μg/kg SeMet 补充剂高度保护小鼠免受 DHFD 诱导的肥胖、胰岛素抵抗和肝、肾脂质沉积的影响，其特征是白色脂肪组织米色化过程增强，能量消耗增加。此外，在冷应激下，150μg/kg SeMet 补充剂通过诱导脂肪米色化促进能量消耗来增强小鼠的耐寒性，这表现为脂肪细胞中解偶联蛋白 1（UCP1）的表达增加。同样，SeMet（10μM）促进了从基质血管部分分化出米色脂肪细胞。总之，我们的数据支持最佳的 SeMet 补充可以增强米色化过程，从而减轻 HFD 诱导的肥胖，这为膳食 SeMet 与 2 型糖尿病之间的关系提供了新的见解。
