Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Biol Trace Elem Res. 2024 Jan;202(1):25-33. doi: 10.1007/s12011-023-03649-5. Epub 2023 Apr 1.
At present, the association between circulating selenium and stroke is still in dispute. Thus, this study aimed to ascertain the association with a larger sample size than the previous study, based on the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. In total, 13755 adults over the age of 20 years were included in our study. Multivariate logistic regression models were applied to analyze the correlation between blood selenium levels and stroke. The smooth curve fitting was performed to test the dose-response effects between blood selenium levels and stroke. After adjusting for all confounders, blood selenium levels were negatively associated with stroke (odds ratio [OR] = 0.57, 95% confidence interval [CI]: 0.37-0.87, P = 0.014). In the fully adjusted model, the highest tertile of blood selenium levels was negatively associated with stroke compared with the lowest tertile (OR = 0.70, 95% CI: 0.53-0.93, P for trend = 0.016). Moreover, the relationship between blood selenium levels and stroke was linear. In subgroup analyses, we observed that the test for interactions was significant for body mass index (BMI) and uric acid (P for interaction < 0.05). The negative relationship was stronger in participants with BMI 25-30 kg/m (OR = 0.23, 95% CI: 0.13-0.44, P < 0.001). Therefore, in American adults, the relationship between blood selenium levels and stroke was negative, with a linear tendency. In the future, a cohort study is warranted to further confirm this relationship.
目前，循环硒与中风之间的关联仍存在争议。因此，本研究旨在基于 2011 年至 2018 年的国家健康和营养调查（NHANES），用更大的样本量来确定这种关联。本研究共纳入了 13755 名年龄在 20 岁以上的成年人。采用多变量逻辑回归模型分析血液硒水平与中风之间的相关性。采用平滑曲线拟合来检验血液硒水平与中风之间的剂量-反应关系。在调整了所有混杂因素后，血液硒水平与中风呈负相关（比值比[OR] = 0.57，95%置信区间[CI]：0.37-0.87，P = 0.014）。在完全调整模型中，与最低三分位相比，血液硒水平最高三分位与中风呈负相关（OR = 0.70，95%CI：0.53-0.93，P 趋势= 0.016）。此外，血液硒水平与中风之间呈线性关系。在亚组分析中，我们观察到体重指数（BMI）和尿酸的交互检验具有统计学意义（P < 0.05）。在 BMI 为 25-30 kg/m2 的参与者中，这种负相关关系更强（OR = 0.23，95%CI：0.13-0.44，P < 0.001）。因此，在美国成年人中，血液硒水平与中风之间呈负相关，且呈线性趋势。未来需要进行队列研究来进一步证实这种关系。
