循环硒浓度与脂质蓄积产物呈正相关：一项基于人群的横断面研究。

The Circulating Selenium Concentration Is Positively Related to the Lipid Accumulation Product: A Population-Based Cross-Sectional Study.

机构信息

National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China.

出版信息

Nutrients. 2024 Mar 23;16(7):933. doi: 10.3390/nu16070933.

DOI:10.3390/nu16070933

PMID:38612965

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11013112/

Abstract

The lipid accumulation product (LAP) is a reliable marker of metabolic syndrome, which includes conditions like obesity. However, the correlation between the circulating selenium (CSe) concentration and the LAP is currently unclear. This study aimed to ascertain this correlation. Overall, 12,815 adults aged ≥20 years were enrolled in this study. After adjusting for all the confounding variables, CSe was positively correlated to the LAP (β = 0.41; 95% confidence interval [CI]: 0.28, 0.54; < 0.001). Compared with the lowest quartile of CSe, the highest quartile of CSe was positively related to the LAP (β = 0.16; 95% CI: 0.12, 0.21; < 0.001). Moreover, the correlation between CSe and the LAP revealed a positive non-linear trend. In the subgroup analysis, interaction effects were observed for age, sex, smoking, and stroke ( for interaction < 0.05). The effects were stronger for males (β = 0.64, 95% CI: 0.47, 0.80; < 0.001) and individuals who smoke at the time of the trial (β = 0.64, 95% CI: 0.37, 0.91; < 0.001). In conclusion, our results indicated that CSe was positively correlated with the LAP in a non-linear manner. Future research is warranted to explore their relationship and better understand the mechanisms underlying this association.

摘要

脂联素蓄积产物（LAP）是代谢综合征的可靠标志物，其中包括肥胖等疾病。然而，循环硒（CSe）浓度与 LAP 的相关性目前尚不清楚。本研究旨在确定这种相关性。总体而言，本研究纳入了 12815 名年龄≥20 岁的成年人。在调整了所有混杂变量后，CSe 与 LAP 呈正相关（β=0.41；95%置信区间[CI]：0.28，0.54；<0.001）。与 CSe 的最低四分位数相比，CSe 的最高四分位数与 LAP 呈正相关（β=0.16；95%CI：0.12，0.21；<0.001）。此外，CSe 与 LAP 之间的相关性呈现出正的非线性趋势。在亚组分析中，年龄、性别、吸烟和中风存在交互作用（<0.05）。对于男性（β=0.64，95%CI：0.47，0.80；<0.001）和在试验时吸烟的个体（β=0.64，95%CI：0.37，0.91；<0.001），这种相关性的作用更强。综上所述，我们的研究结果表明，CSe 与 LAP 呈非线性正相关。未来的研究需要进一步探讨它们之间的关系，并深入了解这种关联的机制。