National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Biol Trace Elem Res. 2024 May;202(5):1998-2007. doi: 10.1007/s12011-023-03839-1. Epub 2023 Sep 9.
Our study aimed to examine whether whole blood selenium (WBSe) levels are related to the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio among the general population. A total of 13,470 adults were included and analyzed from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. In multivariable analyses, LnWBSe levels were significantly related to Ln(TG/HDL-C) ratio in fully adjusted model (β = 0.35; 95% confidence interval (CI): 0.22, 0.48; P < 0.001). Furthermore, the highest quartile of LnWBSe levels was positively correlated with Ln(TG/HDL-C) ratio compared with the lowest quartile (β = 0.15; 95% CI: 0.10, 0.20; P for trend < 0.001). In the dose-response analyses, the correlation was non-linear. While LnWBSe levels < 1.10, LnWBSe levels were positively related to Ln(TG/HDL-C) ratio (β = 0.41; 95% CI: 0.31, 0.50; P < 0.001), whereas LnWBSe levels ≥ 1.10, the relationship was not significantly (β = - 0.20; 95% CI: - 0.54, 0.13; P = 0.228). The interaction test was significant for age, sex, total cholesterol (TC), and diastolic blood pressure (DBP) (all P for interaction < 0.05). Overall, WBSe levels were positively related to TG/HDL-C ratio, with a non-linear trend. Further research is required to determine these underlying mechanisms.
我们的研究旨在探讨全血硒（WBSe）水平与普通人群中甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值之间的关系。本研究共纳入了 13470 名成年人，并对其进行了分析，数据来源于 2011-2018 年国家健康和营养调查（NHANES）。在多变量分析中，在完全调整模型中，LnWBSe 水平与 Ln（TG/HDL-C）比值呈显著正相关（β=0.35；95%置信区间：0.22，0.48；P<0.001）。此外，与最低四分位组相比，LnWBSe 水平最高四分位组与 Ln（TG/HDL-C）比值呈正相关（β=0.15；95%置信区间：0.10，0.20；P 趋势<0.001）。在剂量-反应分析中，相关性是非线性的。当 LnWBSe 水平<1.10 时，LnWBSe 水平与 Ln（TG/HDL-C）比值呈正相关（β=0.41；95%置信区间：0.31，0.50；P<0.001），而当 LnWBSe 水平≥1.10 时，这种关系不显著（β= -0.20；95%置信区间：-0.54，0.13；P=0.228）。年龄、性别、总胆固醇（TC）和舒张压（DBP）的交互检验均有统计学意义（所有 P 交互<0.05）。总的来说，WBSe 水平与 TG/HDL-C 比值呈正相关，且呈非线性趋势。需要进一步研究以确定这些潜在机制。
