Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, PR China.
Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China.
Phytochemistry. 2023 Feb;206:113526. doi: 10.1016/j.phytochem.2022.113526. Epub 2022 Nov 26.
Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached increasing attention due to its multiple pharmacological activities. In this review, the information on hyperforin was systematically summarized. Hyperforin is considered to be a lead compound with diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes and others. It can be obtained by extraction and synthesis. Further pharmacological studies and more precise detection methods will help develop a value for hyperforin. In addition, structural modification and pharmaceutical preparation technology will be beneficial to promoting the research progress of hyperforin based innovative drugs. Although these works are full of known and unknown challenges, researchers are still expected to make hyperforin play a greater value.
贯叶金丝桃（藤黄科），俗称贯叶连翘，作为最古老和研究最广泛的草药之一，具有丰富的历史背景。金丝桃素是贯叶连翘的主要抗抑郁活性成分。近年来，金丝桃素因其多种药理活性而受到越来越多的关注。在这篇综述中，系统总结了金丝桃素的信息。金丝桃素被认为是一种具有多种药理活性的先导化合物，包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。它可以通过提取和合成获得。进一步的药理研究和更精确的检测方法将有助于开发金丝桃素的价值。此外，结构修饰和药物制剂技术将有利于促进基于金丝桃素的创新药物的研究进展。尽管这些工作充满了已知和未知的挑战，但研究人员仍有望使金丝桃素发挥更大的价值。
