Saito-Sasaki Natsuko, Sawada Yu
Department of Dermatology, University of Occupational and Environmental Health, Fukuoka 807-0804, Japan.
Diagnostics (Basel). 2023 Jan 30;13(3):502. doi: 10.3390/diagnostics13030502.
It is understood that the skin is a peripheral lymphoid tissue that defends against external environmental stimuli. Continuous activation from these factors, on the other hand, promotes persistent inflammation at the local location and, occasionally, tissue damage. Hidradenitis suppurativa (HS) is a typical inflammatory skin disease and becomes a source of numerous inflammatory cytokines due to the chronic intractable repeated inflamed tissues. Because inflammatory cells and cytokines circulate throughout the body from the inflamed organ, it has been hypothesized that HS-mediated skin inflammation impacts the systemic functioning of numerous organs. Recent updates to clinical and experimental investigations revealed that HS has a significant connection with systemic inflammatory disorders. We provide the details and comprehensive molecular mechanisms associated with systemic inflammatory illnesses due to HS.
据了解，皮肤是抵御外部环境刺激的外周淋巴组织。另一方面，这些因素的持续激活会促进局部持续炎症，偶尔还会导致组织损伤。化脓性汗腺炎（HS）是一种典型的炎症性皮肤病，由于慢性顽固性反复发炎的组织，它成为众多炎性细胞因子的来源。由于炎症细胞和细胞因子从发炎器官循环至全身，因此有人推测HS介导的皮肤炎症会影响许多器官的全身功能。临床和实验研究的最新进展表明，HS与全身性炎症性疾病有显著关联。我们提供了与HS引起的全身性炎症性疾病相关的详细信息和全面分子机制。
