EA4684 Cardiovir Research Laboratory, University of Reims Champagne-Ardenne, Reims, France.
Internal Medicine, Infectious Diseases and Clinical Immunology, Robert Debré University Hospital, Reims, France.
J Med Virol. 2023 Jan;95(1):e28361. doi: 10.1002/jmv.28361.
We assessed relationships between early peripheral blood type I interferons (IFN) levels, clinical new early warning scores (NEWS), and clinical outcomes in hospitalized coronavirus disease-19 (COVID-19) adult patients. Early IFN-β levels were lower among patients who further required intensive care unit (ICU) admission than those measured in patients who did not require an ICU admission during severe acute respiratory syndrome coronavirus type 2 infection. IFN-β levels were inversely correlated with NEWS only in the subgroup of patients who further required ICU admission. To assess whether peripheral blood IFN-β levels could be a potential relevant biomarker to predict further need for ICU admission, we performed receiver operating characteristic (ROC) curve analyses that showed for all study patients an area under ROC curve of 0.77 growing to 0.86 (p = 0.003) when the analysis was restricted to a subset of patients with NEWS ≥5 at the time of hospital admission. Overall, our findings indicated that early peripheral blood IFN-β levels might be a relevant predictive marker of further need for an ICU admission in hospitalized COVID-19 adult patients, specifically when clinical score (NEWS) was graded as upper than 5 at the time of hospital admission.
我们评估了住院的 2019 冠状病毒病（COVID-19）成年患者早期外周血 I 型干扰素（IFN）水平、临床新早期预警评分（NEWS）与临床结局之间的关系。与严重急性呼吸综合征冠状病毒 2 型感染期间不需要入住重症监护病房（ICU）的患者相比，进一步需要 ICU 收治的患者早期 IFN-β水平较低。IFN-β水平仅与进一步需要 ICU 收治的患者亚组的 NEWS 呈负相关。为评估外周血 IFN-β水平是否可作为预测进一步需要 ICU 收治的潜在相关生物标志物，我们进行了受试者工作特征（ROC）曲线分析，结果显示对于所有研究患者，当分析仅限于入院时 NEWS≥5 的患者亚组时，ROC 曲线下面积从 0.77 增长到 0.86（p=0.003）。总体而言，我们的研究结果表明，早期外周血 IFN-β水平可能是住院 COVID-19 成年患者进一步需要 ICU 收治的一个相关预测标志物，特别是在入院时临床评分（NEWS）被评为大于 5 分时。
