Chethana R, Mishra Prasun, Kaushik Maitri, Jadhav Rohit, Dehadaray Arun
ENT Bharati Vidyapeet (Deemed to be) University Medical College, Pune, Maharashtra India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):956-959. doi: 10.1007/s12070-020-02026-1. Epub 2020 Aug 7.
Nasal mucociliary clearance (NMC) system is an important defence mechanism in respiratory tract. The contents present in the smoke are found to be toxic to cilia in vitro. Our study aims at evaluating the NMC in smokers so as to know effect of tobacco smoke on ciliary function and also comparing it with non smokers. We also studied effect of duration, intensity and pattern of smoking on the NMC. A total of 60 participants in the age group 21-40 years (30 smokers and 30 non smokers) were included in the study. Saccharin test was performed in all participants. A 0.5 mm diameter particle of saccharin was placed 1 cm from the anterior end of the inferior nasal turbinate. The time duration was noted for the first appearance of sweet taste. The mean NMC in smoker group was 16.53 min and in nonsmoker group was 9.28 min On comparison it was found that NMC time in smoker group was significantly higher than nonsmoker group < 0.001 also a positive correlation noted between pack years of smoking and NMC. Saccharin test is a simple test to assess NMC. The prolonged NMC in smokers may be due to reduced ciliary activity or due to changes in viscoelastic properties.
鼻黏液纤毛清除（NMC）系统是呼吸道中的一种重要防御机制。研究发现，烟雾中的成分在体外对纤毛有毒性。我们的研究旨在评估吸烟者的NMC，以了解烟草烟雾对纤毛功能的影响，并与非吸烟者进行比较。我们还研究了吸烟的持续时间、强度和方式对NMC的影响。本研究共纳入60名年龄在21 - 40岁之间的参与者（30名吸烟者和30名非吸烟者）。对所有参与者进行了糖精试验。将直径0.5毫米的糖精颗粒放置在下鼻甲前端1厘米处。记录首次出现甜味的时间。吸烟者组的平均NMC为16.53分钟，非吸烟者组为9.28分钟。比较发现，吸烟者组的NMC时间显著高于非吸烟者组（P < 0.001），吸烟包年数与NMC之间也存在正相关。糖精试验是评估NMC的一种简单试验。吸烟者NMC延长可能是由于纤毛活动减少或黏弹性特性改变所致。
