Department of Uveitis and Ocular Immunology, Manipal Hospital, Bengaluru, India.
Department of Rheumatology, Manipal Hospital, Bengaluru, India.
Indian J Ophthalmol. 2022 Dec;70(12):4445-4448. doi: 10.4103/ijo.IJO_1089_22.
A 35-year-old Asian Indian female previously diagnosed with bilateral anterior uveitis and on oral methotrexate developed bilateral anterior uveitis following first/second dose of coronavirus disease 2019 (COVID-19) vaccination. She had skipped her weekly dose of oral methotrexate following first dose of vaccination. Following the second dose, she reduced her oral methotrexate from 25 to 15 mg on her own, but did not stop like the previous occasion. She had extensive workup for her uveitis in the past with only positive severe acute respiratory syndrome coronavirus (SARS-CoV-2) antibodies. She developed unilateral anterior uveitis after she had COVID-19 in July 2022, which resolved with topical steroids and continuation of immunosuppression. This report illustrates that COVID-19 or its vaccination may presumably play a role in triggering the immune system and can cause recurrent ocular inflammation even in the absence of an extraocular inflammation.
一位 35 岁的亚裔印度女性，此前被诊断为双侧前葡萄膜炎，正在服用口服甲氨蝶呤治疗，在接种新型冠状病毒 2019 型（COVID-19）疫苗第一/二剂后出现双侧前葡萄膜炎。她在接种第一剂疫苗后跳过了每周一次的口服甲氨蝶呤剂量。第二剂后，她自行将口服甲氨蝶呤的剂量从 25 毫克减少到 15 毫克，但不像上次那样停药。她过去曾因葡萄膜炎进行过广泛的检查，只有严重急性呼吸综合征冠状病毒（SARS-CoV-2）抗体呈阳性。她在 2022 年 7 月感染 COVID-19 后出现单侧前葡萄膜炎，经局部皮质类固醇和免疫抑制治疗后缓解。本报告表明，COVID-19 或其疫苗接种可能会在一定程度上引发免疫系统，并可能导致眼部炎症反复发作，即使没有眼外炎症。
