Husband A J
Res Vet Sci. 1978 Sep;25(2):173-7.
An intestinal immunisation procedure involving systemic priming and oral boosting was investigated in lambs with a view to providing vaccination control of enteritis in young animals. The procedure stimulated the appearance of antibody-containing cells of IgA specificity in the intestine and lambs immunised in this way with a bacterial vaccine were protected against subsequent challenge with live enteropathogenic bacteria. This immunisation regime therefore provides a useful method for the stimulation of IgA immunity in the intestine of ruminants and it is anticipated that it will have general application to a variety of enteric diseases.
