Shestovskaya Maria V, Luss Anna L, Bezborodova Olga A, Makarov Valentin V, Keskinov Anton A
Federal State Budgetary Institution "Centre for Strategic Planning and Management of Biomedical Health Risks" of the Federal Medical Biological Agency, Schukinskaya st. 5/1, Moscow 119435, Russia.
The Department of Technology of Chemical, Pharmaceutical and Cosmetic Products Mendeleev of University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russia.
Pharmaceutics. 2023 Sep 30;15(10):2406. doi: 10.3390/pharmaceutics15102406.
The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is widely discussed, but the range of mechanisms studied is not sufficiently codified and often does not reflect the ability of nanocarriers to have a specific impact on cells. This review is focused on the magnetic iron oxide nanoparticles while they occupied a special niche among the prospective radiosensitizers due to unique physicochemical characteristics and reactivity. We collected data about the possible molecular mechanisms underlying the radiosensitizing effects of iron oxide nanoparticles (IONPs) and the main approaches to increase their therapeutic efficacy by variable modifications.
放射增敏的主要概念是使肿瘤组织对电离辐射更敏感，这会提高放射治疗的效力，并允许降低辐射剂量以及随之而来的副作用。金属氧化物纳米颗粒的放射增敏作用已得到广泛讨论，但所研究的作用机制范围尚未得到充分整理，且往往无法反映纳米载体对细胞产生特定影响的能力。本综述聚焦于磁性氧化铁纳米颗粒，因其独特的物理化学特性和反应性，它们在潜在的放射增敏剂中占据特殊地位。我们收集了有关氧化铁纳米颗粒（IONPs）放射增敏作用潜在分子机制的数据，以及通过各种修饰提高其治疗效果的主要方法。
