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Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma.

作者信息

Spaan Ingrid, van Nieuwenhuijzen Niels, Kimman Thomas, Rockx-Brouwer Dedeke, Tieland Ralph G, Maurice Madelon M, Minnema Monique C, Raymakers Reinier A, Peperzak Victor

机构信息

Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

出版信息

Blood Adv. 2023 Apr 11;7(7):1103-1107. doi: 10.1182/bloodadvances.2022008442.

DOI:10.1182/bloodadvances.2022008442
PMID:36459495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10111341/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/10111341/522a96f4db60/BLOODA_ADV-2022-008442-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/10111341/c2fe895934b9/BLOODA_ADV-2022-008442-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/10111341/522a96f4db60/BLOODA_ADV-2022-008442-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/10111341/c2fe895934b9/BLOODA_ADV-2022-008442-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/10111341/522a96f4db60/BLOODA_ADV-2022-008442-gr2.jpg

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Haematologica. 2022 Apr 1;107(4):980-983. doi: 10.3324/haematol.2021.279517.
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MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells.MZB1 能够在受刺激的浆细胞样树突状细胞中有效分泌干扰素 α。
Sci Rep. 2020 Dec 14;10(1):21626. doi: 10.1038/s41598-020-78293-3.
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IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.
IFI6 耗竭通过线粒体功能障碍和内质网应激导致活性氧积累抑制食管鳞状细胞癌进展。
J Exp Clin Cancer Res. 2020 Jul 29;39(1):144. doi: 10.1186/s13046-020-01646-3.
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XBP-1 and the unfolded protein response (UPR).XBP-1与未折叠蛋白反应（UPR）。
Nat Immunol. 2020 Sep;21(9):963-965. doi: 10.1038/s41590-020-0708-3.
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Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options.异常的 Wnt 信号通路在多发性骨髓瘤中的作用：分子机制和靶向治疗选择。
Leukemia. 2019 May;33(5):1063-1075. doi: 10.1038/s41375-019-0404-1. Epub 2019 Feb 15.
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