School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
Department of Biomedical Engineering, Islamic Azad University Central Tehran Branch, Tehran, Iran.
J Therm Biol. 2022 Dec;110:103371. doi: 10.1016/j.jtherbio.2022.103371. Epub 2022 Oct 11.
Numerical simulation of magnetic nanoparticle hyperthermia for cancer treatment has been investigated in this study. The presented simulation did account for the effects of fluid flow, mass flow, and heat transfer during the MNP hyperthermia. The tumor was assumed to be a porous slab, 30% of which had been necrosed previously, with two capillaries, where magnetic nanoparticles were added into the bloodstream and distributed in the tumor by blood flow through capillaries. Fluid flow, mass transfer by capillaries, and interstitial tissues have been coupled in this study. Furthermore, tumor tissue damage has been calculated using a thermal damage indicator. The goal of this research is to find an optimum injection duration and exposure time in order to maximize hyperthermia treatment effectiveness using the BOBYQA optimization method. At the end of the 1-h time hyperthermia treatment, most of the non-necrotic tissue of the tumor were damaged. Moreover, the fraction of damaged tissue increased to more than 90% in some parts of the tumor. Results of this study indicate that MNP hyperthermia with the proposed setup can effectively damage the tumor in just one session, making it more susceptible to complementary therapies such as radiotherapy or chemotherapy.
本研究探讨了用于癌症治疗的磁性纳米粒子热疗的数值模拟。所提出的模拟考虑了在 MNP 热疗过程中流体流动、质量流动和传热的影响。假设肿瘤为多孔平板，其中 30%先前已经坏死，有两个毛细血管，磁性纳米粒子通过毛细血管中的血流添加到血液中并分布在肿瘤中。在本研究中，流体流动、毛细血管中的质量传递和间质组织已经进行了耦合。此外，使用热损伤指标计算了肿瘤组织的损伤。本研究的目的是找到最佳的注射持续时间和暴露时间，以便使用 BOBYQA 优化方法最大限度地提高热疗效果。在 1 小时热疗治疗结束时，肿瘤的大部分非坏死组织都受到了损伤。此外，在肿瘤的某些部位，受损组织的比例增加到 90%以上。本研究结果表明，采用所提出的设置进行 MNP 热疗可以在一次治疗中有效地损伤肿瘤，使其更容易受到放疗或化疗等补充疗法的影响。
