Etminan Andisheh, Salimibani Milad, Dahaghin Ali, Haghpanahi Mohammad, Maleki Ali
School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
Comput Biol Med. 2023 May;157:106771. doi: 10.1016/j.compbiomed.2023.106771. Epub 2023 Mar 10.
In this study, simulation of magnetic nanoparticle hyperthermia is performed on a 3D tumor model constructed based on a CT image of a tumor. In the first step, magnetic nanoparticles are injected into two points of the tumor tissue with the same parameters. Results show that temperature profiles in the vicinity of the injection points are not similar due to the presence of blood capillaries. Therefore, the effects of using dissimilar injection parameters for the two injection points on the heating pattern and damage fraction of the tumor are investigated. The results demonstrate that using dissimilar values for injection parameters such as injection rate, injection time, and nanofluid volume fraction is a way to achieve a higher damage fraction of the tumor cells, but, the asynchronous injections strategy does not lead to more significant damage to the tumor. None of the cases showed significant improvement in the uniformity of the temperature distribution, suggesting that conducting injections under the same conditions is the best way to create an almost uniform temperature profile. The numerical simulation validation results also advocate the accuracy of the model used in this study. This research can serve as a guide for designing parameters for future studies.
在本研究中，对基于肿瘤CT图像构建的三维肿瘤模型进行了磁性纳米颗粒热疗模拟。第一步，以相同参数将磁性纳米颗粒注入肿瘤组织的两个点。结果表明，由于存在毛细血管，注射点附近的温度分布并不相似。因此，研究了对两个注射点使用不同注射参数对肿瘤加热模式和损伤分数的影响。结果表明，对注射速率、注射时间和纳米流体体积分数等注射参数使用不同值是实现更高肿瘤细胞损伤分数的一种方法，但是，异步注射策略并不会导致对肿瘤更显著的损伤。所有情况均未显示温度分布均匀性有显著改善，这表明在相同条件下进行注射是创建几乎均匀温度分布的最佳方法。数值模拟验证结果也支持本研究中使用的模型的准确性。本研究可为未来研究的参数设计提供指导。
