Sung Wang Yu, Tsai Wen Chan
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan, China.
Rheumatol Immunol Res. 2021 Apr 13;2(1):19-25. doi: 10.2478/rir-2021-0003. eCollection 2021 Mar.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint inflammation and extra-articular manifestations. Many questions in the pathogenesis, clinical manifestation, and disease spectrum are answered after the discovery of the first autoantibody namely rheumatoid factor (RF). The finding of the second autoantibody named anti-citrullinated protein antibody (ACPA), which unearths the importance of protein citrullination process. It further provides the insight how immune cells and complement interact to perpetuate the inflammatory response. These two autoantibodies pave the way for our better understanding of RA. This review article focuses on the history, pathophysiology, and clinical association of these two autoantibodies in RA.
类风湿关节炎（RA）是一种慢性炎症性自身免疫性疾病，其特征为关节炎症和关节外表现。在发现第一种自身抗体即类风湿因子（RF）之后，关于发病机制、临床表现和疾病谱的许多问题得到了解答。第二种自身抗体抗瓜氨酸化蛋白抗体（ACPA）的发现，揭示了蛋白质瓜氨酸化过程的重要性。它进一步提供了关于免疫细胞和补体如何相互作用以维持炎症反应的见解。这两种自身抗体为我们更好地理解RA铺平了道路。这篇综述文章重点关注这两种自身抗体在RA中的历史、病理生理学及临床关联。
