Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Org Lett. 2022 Dec 16;24(49):9107-9111. doi: 10.1021/acs.orglett.2c03769. Epub 2022 Dec 5.
Sarglaoxolane A (), the first lindenane-normonoterpene heterodimer fused by tetrahydrofuran, was discovered in guided by the first proposed single-node-based molecular networking approach. Moreover, two pseudonatural derivatives ( and ) with an oxa-difuranofurone moiety were transformed from and confirmed by X-ray diffraction, and also proven to exist in the plant extract. A combination of molecular networking and biomimetic transformation can significantly promote the discovery and structural elucidation of novel natural products.
Sarglaoxolane A ()，第一个由四氢呋喃连接的里那烷-降诺木萜烯杂二聚体，是在基于首次提出的单节点分子网络方法的指导下发现的。此外，两个具有氧杂二呋喃酮部分的假天然衍生物（和）从和转化而来，并通过 X 射线衍射证实，也被证明存在于植物提取物中。分子网络和仿生转化的结合可以显著促进新型天然产物的发现和结构阐明。
