几丁质合成酶的结构与机制及其受抗真菌药物多氧霉素Z的抑制作用 - Suppr

Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

作者信息

Wu Yanan, Zhang Min, Yang Yizheng, Ding Xuyang, Yang Ping, Huang Kai, Hu Xinlin, Zhang Mingjie, Liu Xiaotian, Yu Hongjun

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Cell Discov. 2022 Dec 6;8(1):129. doi: 10.1038/s41421-022-00495-y.

DOI:10.1038/s41421-022-00495-y

PMID:36473834

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9726829/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfe/9726829/e0d7c3d8bfae/41421_2022_495_Fig1_HTML.jpg

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Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

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Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

J Bacteriol. 1994 Sep;176(18):5857-60. doi: 10.1128/jb.176.18.5857-5860.1994.

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Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.

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Nikkomycin Z counteracts Rylux BSU and Congo red inhibition of Saccharomyces cerevisiae growth but does not prevent formation of aberrant cell walls.

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Crystallographic snapshot of cellulose synthesis and membrane translocation.

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Annu Rev Biochem. 2008;77:521-55. doi: 10.1146/annurev.biochem.76.061005.092322.

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Antimicrob Agents Chemother. 2000 Jun;44(6):1624-9. doi: 10.1128/AAC.44.6.1624-1629.2000.

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

J Bacteriol. 1994 Sep;176(18):5857-60. doi: 10.1128/jb.176.18.5857-5860.1994.

Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae.

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Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins.

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Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

作者信息

Wu Yanan, Zhang Min, Yang Yizheng, Ding Xuyang, Yang Ping, Huang Kai, Hu Xinlin, Zhang Mingjie, Liu Xiaotian, Yu Hongjun

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Cell Discov. 2022 Dec 6;8(1):129. doi: 10.1038/s41421-022-00495-y.

DOI:10.1038/s41421-022-00495-y

PMID:36473834

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9726829/

Abstract

摘要

相似文献

Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

Cell Discov. 2022 Dec 6;8(1):129. doi: 10.1038/s41421-022-00495-y.

Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicans.

Yeast. 2002 Mar 15;19(4):341-9. doi: 10.1002/yea.837.

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

J Bacteriol. 1994 Sep;176(18):5857-60. doi: 10.1128/jb.176.18.5857-5860.1994.

Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z.

Antimicrob Agents Chemother. 1992 Sep;36(9):1909-14. doi: 10.1128/AAC.36.9.1909.

Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms.

Lett Appl Microbiol. 2019 Oct;69(4):271-278. doi: 10.1111/lam.13204. Epub 2019 Aug 23.

Antifungal activity of nikkomycin Z against Candida auris.

J Antimicrob Chemother. 2021 May 12;76(6):1495-1497. doi: 10.1093/jac/dkab052.

Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.

Nat Struct Mol Biol. 2022 Jul;29(7):653-664. doi: 10.1038/s41594-022-00791-x. Epub 2022 Jul 4.

Chitin synthase inhibitors as antifungal agents.

Mini Rev Med Chem. 2013 Feb;13(2):222-36. doi: 10.2174/138955713804805256.

Nikkomycin Z counteracts Rylux BSU and Congo red inhibition of Saccharomyces cerevisiae growth but does not prevent formation of aberrant cell walls.

Folia Microbiol (Praha). 1999;44(6):663-8. doi: 10.1007/BF02825658.

Efficacy of nikkomycin Z against experimental pulmonary blastomycosis.

Antimicrob Agents Chemother. 1997 Sep;41(9):2026-8. doi: 10.1128/AAC.41.9.2026.

引用本文的文献

Antifungal Drugs for the Treatment of Invasive Fungal Infections-A Limited Therapeutic Toolbox Facing Growing Resistances.

Pharmaceuticals (Basel). 2025 Aug 19;18(8):1220. doi: 10.3390/ph18081220.

Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China.

BMC Microbiol. 2025 Aug 8;25(1):490. doi: 10.1186/s12866-025-04155-5.

Biological efficacy of polyoxin D in crop protection.

J Pestic Sci. 2025 May 20;50(2):19-30. doi: 10.1584/jpestics.D24-055.

Pharmacokinetics of nikkomycin Z following multiple doses in healthy subjects.

Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0039525. doi: 10.1128/aac.00395-25. Epub 2025 Jun 6.

Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways.

Pharmaceuticals (Basel). 2025 Mar 4;18(3):364. doi: 10.3390/ph18030364.

Metabolic engineering approaches for the biosynthesis of antibiotics.

Microb Cell Fact. 2025 Jan 31;24(1):35. doi: 10.1186/s12934-024-02628-2.

Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains of Isolated from Rhizospheric Soils.

Microorganisms. 2024 Dec 19;12(12):2637. doi: 10.3390/microorganisms12122637.

In vitro and In silico investigation deciphering novel antifungal activity of endophyte Bacillus velezensis CBMB205 against Fusarium oxysporum.

Sci Rep. 2025 Jan 3;15(1):684. doi: 10.1038/s41598-024-77926-1.

Late-stage diversification of bacterial natural products through biocatalysis.

Front Bioeng Biotechnol. 2024 May 14;12:1351583. doi: 10.3389/fbioe.2024.1351583. eCollection 2024.

Advancements and challenges in antifungal therapeutic development.

Clin Microbiol Rev. 2024 Mar 14;37(1):e0014223. doi: 10.1128/cmr.00142-23. Epub 2024 Jan 31.

本文引用的文献

Structure, substrate recognition and initiation of hyaluronan synthase.

Nature. 2022 Apr;604(7904):195-201. doi: 10.1038/s41586-022-04534-2. Epub 2022 Mar 30.

Nikkomycin Z against Disseminated Coccidioidomycosis in a Murine Model of Sustained-Release Dosing.

Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0028521. doi: 10.1128/AAC.00285-21. Epub 2021 Jul 12.

The fungal cell wall as a target for the development of new antifungal therapies.

Biotechnol Adv. 2019 Nov 1;37(6):107352. doi: 10.1016/j.biotechadv.2019.02.008. Epub 2019 Feb 21.

The antifungal pipeline: a reality check.

Nat Rev Drug Discov. 2017 Sep;16(9):603-616. doi: 10.1038/nrd.2017.46. Epub 2017 May 12.

Crystallographic snapshot of cellulose synthesis and membrane translocation.

Nature. 2013 Jan 10;493(7431):181-6. doi: 10.1038/nature11744. Epub 2012 Dec 9.

Glycosyltransferases: structures, functions, and mechanisms.

Annu Rev Biochem. 2008;77:521-55. doi: 10.1146/annurev.biochem.76.061005.092322.

Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model.

Antimicrob Agents Chemother. 2000 Jun;44(6):1624-9. doi: 10.1128/AAC.44.6.1624-1629.2000.

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

J Bacteriol. 1994 Sep;176(18):5857-60. doi: 10.1128/jb.176.18.5857-5860.1994.

Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae.

J Biol Chem. 1986 Nov 15;261(32):15147-52.

Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins.

Antimicrob Agents Chemother. 1991 Jan;35(1):170-3. doi: 10.1128/AAC.35.1.170.

Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

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Structures and mechanism of chitin synthase and its inhibition by antifungal drug Nikkomycin Z.

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