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尼克霉素Z在体外和体内都是酿酒酵母几丁质合成酶同工酶Chs3的特异性抑制剂。

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

作者信息

Gaughran J P, Lai M H, Kirsch D R, Silverman S J

机构信息

Molecular Genetic Screen Design, Agricultural Research Division, American Cyanamid, Princeton, New Jersey 08543.

出版信息

J Bacteriol. 1994 Sep;176(18):5857-60. doi: 10.1128/jb.176.18.5857-5860.1994.

DOI:10.1128/jb.176.18.5857-5860.1994
PMID:8083179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC196793/
Abstract

Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin synthase isozymes and growth assays with isozyme mutants were used to demonstrate that nikkomycin Z is a selective inhibitor of chitin synthase 3. The resistance of chitin synthase 2 to nikkomycin Z in vitro is likely responsible for the poor activity of this antibiotic against Saccharomyces cerevisiae.

摘要

尼可霉素Z在体外可抑制几丁质合成酶，但对许多病原体并无抗真菌活性。通过对几丁质合成酶同工酶的测定以及对同工酶突变体的生长测定，证实尼可霉素Z是几丁质合成酶3的选择性抑制剂。几丁质合成酶2在体外对尼可霉素Z具有抗性，这可能是该抗生素对酿酒酵母活性不佳的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/196793/e888d422fdbc/jbacter00036-0285-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/196793/e0c2aafb9191/jbacter00036-0285-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/196793/e888d422fdbc/jbacter00036-0285-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/196793/e0c2aafb9191/jbacter00036-0285-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ae/196793/e888d422fdbc/jbacter00036-0285-b.jpg

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