Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, No.639 Zhizaoju Road, Huangpu District, Shanghai, 200011, People's Republic of China.
Department of Neurosurgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
BMC Psychiatry. 2022 Dec 6;22(1):769. doi: 10.1186/s12888-022-04415-y.
The purpose of this study is to investigate the possible link between dietary theobromine intake and symptoms of depression.
These results are based on the responses of 3637 people who took part in the National Health and Nutrition Examination Survey in 2017-2018. Participants' daily theobromine intake was determined using a 24-h food questionnaire from the 2017-2018 cycle. Presence of depression was defined as a score of 5 or above on the Patient Health Questionnaire. Association between theobromine intake and depression was examined using a multivariate logistic regression adjusting for several relevant sociodemographic, lifestyle and health-related factors.
A total of 6903 participants were included in the study. The results of multivariate logistic regression showed a correlation between depressive symptoms and theobromine intake (OR:1.17, 95%CI:1.02-1.34).
Our cross-sectional population based study suggests that increased theobromine intake is associated with increased risk for depression. Nevertheless, more investigations are needed to confirm our findings.
本研究旨在探讨饮食可可碱摄入量与抑郁症状之间可能存在的联系。
这些结果基于 2017-2018 年参加国家健康和营养检查调查的 3637 人的反应。参与者的日常可可碱摄入量是通过 2017-2018 周期的 24 小时食物问卷确定的。抑郁的存在是通过患者健康问卷的 5 分或以上来定义的。使用多变量逻辑回归来检查可可碱摄入与抑郁之间的关联，调整了几个相关的社会人口统计学、生活方式和与健康相关的因素。
共有 6903 名参与者纳入研究。多变量逻辑回归的结果显示，抑郁症状与可可碱摄入之间存在相关性（OR：1.17，95%CI：1.02-1.34）。
我们的基于横断面人群的研究表明，可可碱摄入量增加与抑郁风险增加有关。然而，需要进一步的研究来证实我们的发现。
