Dai X, Cao X, Jiang Q, Wu B, Lou T, Shao Y, Hu Y, Lan Q
From the Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, P. R. China.
Department of Clinical Medicine, The First Clinical College of Anhui Medical University, Hefei 230032, P. R. China.
QJM. 2023 Mar 27;116(3):161-180. doi: 10.1093/qjmed/hcac272.
Corona Virus Disease 2019 (COVID-19) has caused several pandemic peaks worldwide due to its high variability and infectiousness, and COVID-19 has become a long-standing global public health problem. There is growing evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) frequently causes multi-organ injuries and more severe neurological manifestations. Therefore, increased awareness of possible neurological complications is beneficial in preventing and mitigating the impact of long-term sequelae and improving the prognostic outcome of critically ill patients with COVID-19. Here, we review the main pathways of SARS-CoV-2 neuroinvasion and the potential mechanisms causing neurological damage. We also discuss in detail neurological complications, aiming to provide cutting-edge basis for subsequent related basic research and clinical studies of diagnosis and treatment.
2019冠状病毒病（COVID-19）因其高度变异性和传染性在全球引发了多次疫情高峰，已成为一个长期存在的全球公共卫生问题。越来越多的证据表明，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）经常导致多器官损伤和更严重的神经表现。因此，提高对可能出现的神经并发症的认识，有利于预防和减轻长期后遗症的影响，并改善COVID-19危重症患者的预后。在此，我们综述了SARS-CoV-2神经侵袭的主要途径以及导致神经损伤的潜在机制。我们还详细讨论了神经并发症，旨在为后续相关基础研究以及诊断和治疗的临床研究提供前沿依据。
