Dekker A, Bupp P A
Am J Clin Pathol. 1978 Dec;70(6):855-60. doi: 10.1093/ajcp/70.6.855.
Approximately half of 351 body-cavity effusions from 263 patients were examined prospectively in paraffin-embedded cell blocks and in smears, while the other half were examined in smears alone. The number of suspect and positive fluids obtained with the combined cell block-and-smear technic was double that of specimens examined in smears only. No false-positive case was found. Tumors were subsequently demonstrated in 38% of the patients who had negative or atypical cytologic reports. Smears stained with the Papanicolaou technic generally have good definition of malignant cellular changes, wheras cell blocks are particularly useful when the cytologic abnormalities are misleading, such as in reactive mesothelial cells, or obscure, as in occasional well-differentiated adenocarcinomas. It is recommended that both cell blocks and smears be used in evaluating all fluids submitted to the cytology laboratory.
对263例患者的351份体腔积液中的大约一半进行了前瞻性研究，采用石蜡包埋细胞块和涂片检查，另一半仅进行涂片检查。联合细胞块和涂片技术获得的可疑和阳性积液数量是仅进行涂片检查标本的两倍。未发现假阳性病例。随后在38%细胞学报告为阴性或不典型的患者中发现了肿瘤。用巴氏染色法染色的涂片通常能很好地显示恶性细胞变化，而当细胞学异常具有误导性（如反应性间皮细胞）或不明显（如偶尔的高分化腺癌）时，细胞块特别有用。建议在评估提交给细胞学实验室的所有积液时同时使用细胞块和涂片。
