Department of Respiratory Medicine, Vall d'Hebron University Hospital, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Int J Environ Res Public Health. 2022 Dec 6;19(23):16305. doi: 10.3390/ijerph192316305.
The aim of this study was to analyse the relationship between occupational exposure to asbestos and the severity of SARS-CoV-2 infection.
We evaluated patients who survived admission in our centre for COVID-19 pneumonia. Demographic, analytical, and clinical variables were collected during admission. After discharge, a previously validated occupational exposure to asbestos questionnaire was administered. Spirometry, CO diffusion test, the 6-min walk test, and high-resolution chest CT were performed. Patients who required respiratory support (oxygen, CPAP, or NIV) were considered severe.
In total, 293 patients (mean age 54 + 13 years) were included. Occupational exposure to asbestos was detected in 67 (24%). Patients with occupational exposure to asbestos had a higher frequency of COVID-19 pneumonia requiring respiratory support ( = 52, 77.6%) than their unexposed peers ( = 139, 61.5%) ( = 0.015). Asbestos exposure was associated with COVID-19 severity in the univariate but not in the multivariate analysis. No differences were found regarding follow-up variables including spirometry and the DLCO diffusion, the 6-min walk test, and CT alterations.
In hospitalised patients with COVID-19 pneumonia, those with occupational exposure to asbestos more frequently needed respiratory support. However, an independent association between asbestos exposure and COVID-19 severity could not be confirmed.
本研究旨在分析职业性接触石棉与 SARS-CoV-2 感染严重程度之间的关系。
我们评估了在我们中心因 COVID-19 肺炎住院的存活患者。在住院期间收集了人口统计学、分析和临床变量。出院后，进行了先前验证的职业性接触石棉问卷评估。进行了肺量测定、CO 弥散试验、6 分钟步行试验和高分辨率胸部 CT 检查。需要呼吸支持（氧气、CPAP 或 NIV）的患者被认为是严重的。
共纳入 293 例患者（平均年龄 54 + 13 岁）。检测到 67 例（24%）职业性接触石棉。有职业性接触石棉的患者 COVID-19 肺炎需要呼吸支持的频率（=52，77.6%）高于未接触的同龄人（=139，61.5%）（=0.015）。石棉暴露在单变量分析中与 COVID-19 严重程度相关，但在多变量分析中不相关。在随访变量方面，包括肺量测定和 DLCO 弥散、6 分钟步行试验和 CT 改变，没有发现差异。
在 COVID-19 肺炎住院患者中，职业性接触石棉的患者更频繁地需要呼吸支持。然而，无法确认石棉暴露与 COVID-19 严重程度之间的独立关联。
