Zhang Zhihui, Jia Yan, Tao Liyuan, Liu Xiaodan, Han Ying, Wang Xiao
Department of Stomatology, Peking University Third Hospital, Beijing 100191, China.
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.
J Clin Med. 2022 Nov 27;11(23):7004. doi: 10.3390/jcm11237004.
Background: Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and considered a potential malignant disease, for which a method for complete cure is lacking. The dexamethasone and gentamicin mouthwash, combined with total glucosides of paeony (TGP), was tested in the treatment of OLP patients without fungal infection, with a view to provide evidence that may assist in resolving the dilemma. Methods: A randomized and single-blind clinical trial of 48 non-erosive and erosive OLP patients was conducted, with the patients divided into two groups. Group A was treated with dexamethasone plus gentamycin mouthwash and Group B received an additional TGP capsule together with the aforementioned mouthwash. All the patients were followed up with four times, at 2 weeks, 1 month, 3 months, and 6 months. The clinical manifestations, sign score, and VAS scale were recorded. The total effective rate (%) was defined as (cases of complete resolution + cases of partial resolution)/total cases observed × 100%. Results: A total of 43 patients completed all follow-up appointments. Among the 21 patients in Group A, the total effective rate was 61.9%. Of the 22 patients in Group B, the total effective rate was 89.66%. The clinical manifestation, sign score, and VAS of the two groups all indicated improvements, and there were significant differences between the two groups (p < 0.05). Conclusions: Dexamethasone plus gentamycin mouthwash combined with TGP treatment for OLP patients is a safe and effective treatment of OLP.
口腔扁平苔藓（OLP）是一种常见的口腔黏膜慢性炎症性疾病，被认为是一种潜在的恶性疾病，目前缺乏完全治愈的方法。地塞米松庆大霉素漱口水联合白芍总苷（TGP）用于治疗无真菌感染的OLP患者，旨在提供有助于解决这一困境的证据。方法：对48例非糜烂性和糜烂性OLP患者进行随机单盲临床试验，将患者分为两组。A组用地塞米松加庆大霉素漱口水治疗，B组在上述漱口水基础上加用TGP胶囊。所有患者在2周、1个月、3个月和6个月时进行4次随访。记录临床表现、体征评分和视觉模拟量表（VAS）评分。总有效率（%）定义为（完全缓解病例数+部分缓解病例数）/观察总病例数×100%。结果：共有43例患者完成了所有随访。A组21例患者中，总有效率为61.9%。B组22例患者中，总有效率为89.66%。两组的临床表现、体征评分和VAS评分均有改善，两组间差异有统计学意义（p<0.05）。结论：地塞米松加庆大霉素漱口水联合TGP治疗OLP患者是一种安全有效的治疗方法。
