Mehdipour Masoumeh, Taghavi Zenouz Ali, Bahramian Aila, Yazdani Javad, Pouralibaba Firoz, Sadr Katayoun
Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
J Dent Res Dent Clin Dent Prospects. 2010 Winter;4(1):25-8. doi: 10.5681/joddd.2010.007. Epub 2010 Mar 14.
Lichen planus is a chronic inflammatory disorder with unspecified etiology, appearing as a result of stress, genetic predisposition and immunologic factors. Erosive type of the disease is more important because of its clinical symptoms of pain, irritation and malignancy risk. Despite various medications used, a definite cure for lichen planus is un-known. Regarding the effect of zinc on healing of ulcers, the aim of this study was to compare the effect of a mouthwash with and without zinc and fluocinolone on healing of erosive oral lichen planus.
Twenty randomly-selected patients with erosive oral lichen planus were divided into two groups of 10. One group received zinc mouthwash with fluocinolone ointment and the other group received placebo with ointment. The largest dimension of the ulcers was measured by digital calipers and the intensity of pain was determined by visual ana-logue scale. Data was analyzed with Mann-Whitney U test.
Pain, irritation and lesion surface area decreased in both groups. Decrease in pain severity was identical in both groups (P = 0.11). However, decrease in surface area with zinc mouthwash plus fluocinolone was more than that with only fluocinolone (P = 0.037).
0.2% zinc mouthwash plus fluocinolone and only fluocinolone were both effective in decreasing pain, irrita-tion, and surface area of OLP. However, decrease in surface area with zinc mouthwash plus fluocinolone was more than that with fluocinolone alone.
扁平苔藓是一种病因不明的慢性炎症性疾病，其发病是压力、遗传易感性和免疫因素共同作用的结果。糜烂型扁平苔藓因其疼痛、刺激和恶变风险等临床症状而更为重要。尽管使用了各种药物，但扁平苔藓的确切治愈方法仍不明确。鉴于锌对溃疡愈合的作用，本研究旨在比较含锌和不含锌的漱口水联合氟轻松对糜烂性口腔扁平苔藓愈合的影响。
随机选取20例糜烂性口腔扁平苔藓患者，分为两组，每组10例。一组使用含氟轻松软膏的含锌漱口水，另一组使用含软膏的安慰剂。用数字卡尺测量溃疡的最大尺寸，用视觉模拟量表确定疼痛强度。数据采用曼-惠特尼U检验进行分析。
两组患者的疼痛、刺激症状及病损面积均有所减轻。两组患者疼痛严重程度的降低程度相同（P = 0.11）。然而，含锌漱口水加氟轻松组病损面积的减小幅度大于仅使用氟轻松组（P = 0.037）。
0.2%含锌漱口水加氟轻松和仅使用氟轻松对减轻口腔扁平苔藓的疼痛、刺激症状及病损面积均有效。然而，含锌漱口水加氟轻松组病损面积的减小幅度大于单独使用氟轻松组。
