Meštrović Popovič Katarina, Povalej Bržan Petra, Langerholc Tomaž, Marčun Varda Nataša
General Hospital Celje, Oblakova 5 (omit Splošna bolnišnica Celje), SI-3000 Celje, Slovenia.
Faculty of Medicine, University of Maribor, Taborska ulica 8, SI-2000 Maribor, Slovenia.
J Clin Med. 2022 Nov 27;11(23):7008. doi: 10.3390/jcm11237008.
Urinary tract infections (UTI) are frequent bacterial infections in childhood. Considering the known beneficial effects of probiotics in the gastrointestinal field, they could also help to alleviate UTIs. In our clinical pilot study, we sought to verify the positive effects of the specific probiotic strain on the course and prevention of UTI in children. Thirty children with UTIs were enrolled and sequentially sampled into two groups (placebo/control and probiotic/test) in a double-blind, randomized, placebo-controlled clinical pilot study. We chose PCS 26 (Lp26) derived from local Slovenian cheese in Pathogen Combat Project, which showed a good in vitro antimicrobial effect on Several parameters were followed to look for differences between both groups in the acute phase of the UTI and after 6 months of taking probiotic or placebo supplementation. Our results showed no statistically significant differences between both groups; however, two children in the placebo group suffered a recurrence of febrile UTI within 6 months of the follow-up period, while there were no recurrences of UTI in the probiotic group. In the test group, the number of febrile days after the initiation of antibiotics with probiotics was shorter, although not reaching statistical significance ( = 0.084). According to our results, probiotics might be helpful in alleviating UTI symptoms and in UTI prevention. Further research with a larger sample size is warranted. Additionally, basic scientific studies for the selection of proper immunobiotic strains of probiotics should be performed.
尿路感染（UTI）是儿童期常见的细菌感染。鉴于益生菌在胃肠道领域已知的有益作用，它们也可能有助于缓解尿路感染。在我们的临床初步研究中，我们试图验证特定益生菌菌株对儿童尿路感染病程及预防的积极作用。在一项双盲、随机、安慰剂对照的临床初步研究中，30名患有尿路感染的儿童被纳入并依次分为两组（安慰剂/对照组和益生菌/试验组）。我们在“病原体对抗计划”中选择了源自斯洛文尼亚当地奶酪的PCS 26（Lp26），它在体外对几种病原体显示出良好的抗菌效果。在尿路感染急性期以及服用益生菌或安慰剂补充剂6个月后，跟踪了几个参数以寻找两组之间的差异。我们的结果显示两组之间没有统计学上的显著差异；然而，安慰剂组中有两名儿童在随访期的6个月内出现了发热性尿路感染复发，而益生菌组中没有尿路感染复发。在试验组中，使用益生菌开始使用抗生素后的发热天数较短，尽管未达到统计学意义（P = 0.084）。根据我们的结果，益生菌可能有助于缓解尿路感染症状和预防尿路感染。有必要进行更大样本量的进一步研究。此外，应该进行基础科学研究以选择合适的益生菌免疫生物菌株。
