Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, No.138 Xianlin Avenue, Nanjing 210023, China.
Int J Mol Sci. 2022 Dec 4;23(23):15289. doi: 10.3390/ijms232315289.
Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gastric cancer (GC). Accordingly, thermo-TRPs constitute a major pharmacological target, and the elucidation of the mechanisms underlying their response to physiological stimuli or drugs is key for notable advances in GC treatment. Therefore, this paper summarizes the existing literature about thermo-TRP protein expression changes that are linked to the incidence and progression of GC. The review also discusses the implication of such association to pathology and cell physiology and identifies potential thermo-TRP protein targets for diagnosis and treatment of GC.
在过去的十年中，研究人员发现瞬时受体电位 (TRP) 通道的异常表达。特别是，热敏感子类别的成员（热 TRP）参与了许多疾病过程。此外，它们在胃癌（GC）的发生和发展中起着至关重要的作用。因此，热 TRP 构成了一个主要的药理靶点，阐明其对生理刺激或药物反应的机制对于 GC 治疗的显著进展至关重要。因此，本文总结了与 GC 发生和发展相关的热 TRP 蛋白表达变化的现有文献。该综述还讨论了这种关联对病理学和细胞生理学的意义，并确定了潜在的热 TRP 蛋白靶点，用于 GC 的诊断和治疗。
